Proteases: Potential Role in Health and Disease

Front Matter....Pages i-xv
Physiology and Pathophysiology of Neutral Proteinases of Human Granulocytes....Pages 1-20
Regulation of Protease Activity....Pages 21-40
Human Kininogens and their Function in the Kallikrein-Kinin Systems....Pages 41-62
Possible Involvement of Kinins in Muscle Energy Metabolism....Pages 63-71
Structure and Function of Natural Inhibitors as Antagonists of Proteinase Activities....Pages 73-87
Oxidation of Alpha-1-Proteinase Inhibitor: Significance for Pathobiology....Pages 89-95
In Vivo Significance of Kinetic Constants of Macromolecular Proteinase Inhibitors....Pages 97-109
On the Multiplicity of Cellular Elastases and their Inefficient Control by Natural Inhibitors....Pages 111-119
Proteases - Proteases Inhibitors: A Local Cellular Information System....Pages 121-127
Regulatory Proteolysis during Corticosteroid Hormone Action....Pages 129-140
Proteases in Hormone Production and Metabolism....Pages 141-151
Precursor Processing and Metabolism of Parathyroid Hormone: Regulation by Calcium....Pages 153-164
Processing and Degradation of Met-Enkephalin by Peptidases Associated with Rat Brain Cortical Synaptosomes....Pages 165-177
Characterization and Clinical Significance of Membrane Bound Proteases from Human Kidney Cortex....Pages 179-190
Recent Advances in Protease Research using Synthetic Substrates....Pages 191-207
Kinetic Characterization of Brush Border Membrane Proteases in Relationship to Mucosal Architecture by Section Biochemistry....Pages 209-218
Fluorescence Detection of Proteases with AFC, AMC and MNA Peptides using Isoelectric Focusing....Pages 219-226
Pathophysiology of the Interaction between Complement and Non-Complement Proteases....Pages 227-234
Interactions between the Alternative Complement Pathway and Proteases of the Coagulation System....Pages 235-239
The Calcium-Dependent Neutral Protease of Human Blood Platelets: A Comparison of its Effects on the Receptors for von Willebrand Factor and for the Fc-Fragment Derived from IgG....Pages 241-251
Alpha-2-Plasmin-Inhibitor Inactivation by Human Granulocyte Elastase....Pages 253-261
Heparin and Plasma Proteinase Inhibitors: Influence of Heparin on the Inhibition of Thrombin by α 2 Macroglobulin....Pages 263-272
The Involvement of Plasmatic and Fibrinolytic Systems in Idiopathic Glomerulonephritis (GN)....Pages 273-285
The Effect of Aprotinin on Platelet Function, Blood Coagulation and Blood Lactate Level in Total Hip Replacement - A Double Blind Clinical Trial....Pages 287-297
Interaction of Granulocyte Proteases with Inhibitors in Pulmonary Diseases....Pages 299-312
Leukoproteinases and Pulmonary Emphysema: Cathepsin G and other Chymotrypsin-Like Proteinases Enhance the Elastolytic Activity of Elastase on Lung Elastin....Pages 313-317
Adult Respiratory Distress Syndrome (ARDS): Experimental Models with Elastase and Thrombin Infusion in Pigs....Pages 319-333
Interactions of Granulocyte Proteases with Inhibitors in Rheumatoid Arthritis....Pages 335-344
Quantitation of Human Leukocyte Elastase, Cathepsin G, α-2-Macro-Globulin and α-1-Proteinase Inhibitor in Osteoarthrosis and Rheumatoid Arthritis Synovial Fluids....Pages 345-353
Plasma Levels of Inhibitor-Bound Leukocytic Elastase in Rheumatoid Arthritis Patients....Pages 355-362
a 2 M-Pasebic Assay: A Solid Phase Immunosorbent Assay to Characterize Alpa 2 -Macroglobulin - Proteinase Complexes and the Proteinase Binding-Capacity of Alpha 2 -Macroglobulin....Pages 363-369
Role of Alpha 2 -Macroglobulin: Proteinase Complexes in Pathogenesis of Inflammation - ‘F’ a 2 M But not ‘s’ a 2 M Induces Synovitis in Rabbits after Repeated Intra-Articular Administration....Pages 371-377
Enzyme-Linked Immunoassay for Human Granulocyte Elastase in Complex with α 1 -Proteinase Inhibitor....Pages 379-390
Proteinases and their Inhibitors in Septicemia - Basic Concepts and Clinical Implications....Pages 391-404
Proteolytic Activity in Patients with Hypercatabolic Renal Failure....Pages 405-416
Release of Granulocyte Neutral Proteinases in Patients with Acute and Chronic Renal Failure....Pages 417-431
Changes in Components of The Plasma Kallikrein-Kinin and Fibrinolytic Systems Induced by a Standardized Surgical Trauma....Pages 433-437
Endotoxins and Coagulation Parameters in Patients with Traumatic Haemorrhagic- and Bacteriotoxic Shock....Pages 439-448
Studies on Pathological Plasma Proteolysis in Severely Burned Patients using Chromogenic Peptide Substrate Assays: A Preliminary Report....Pages 449-454
Changes in Components of the Plasma Protease Systems Related to Course and Outcome of Surgical Sepsis....Pages 455-462
Role of Proteases in the Development of Acute Pancreatitis....Pages 463-475
On the Potential Role of Trypsin and Trypsin Inhibitors in Acute Pancreatitis....Pages 477-487
Studies on the Kallikrein-Kinin System in Plasma and Peritoneal Fluid during Experimental Pancreatitis....Pages 489-494
The Influence of the Kallikrein-Kinin System in the Development of the Pancreatic Shock....Pages 495-503
Proteolytic Enzymes and Enhanced Muscle Protein Breakdown....Pages 505-517
Ca 2 - Activated Proteinases, Protein Degradation and Muscular Dystrophy....Pages 519-531
Muscle Cathepsin D Activity, and RNA, DNA and Protein Content in Maintenance Hemodialysis Patients....Pages 533-543
Enhanced Muscle Protein Degradation and Amino Acid Release from the Hemicorpus of Acutely Uremic Rats....Pages 545-555
Enhanced Muscle Protein Catabolism in Uremia....Pages 557-569
Catabolic Stress on Intracellular Amino Acid Pool....Pages 571-579
Rhabdomyolysis: A Clinical Entity for the Study of Role of Proteases....Pages 581-586
Back Matter....Pages 587-591