Inositol and Phosphoinositides: Metabolism and Regulation

Front Matter....Pages i-xxii
Front Matter....Pages 1-1
The Mechanism of Enzymatic Isomerization of Glucose 6-Phosphate to L- Myo -Inositol 1-phosphate....Pages 3-11
Regulation of the Lipid Composition of Lung Surfactant....Pages 13-30
Nutritional Regulation of the Composition, Metabolism, and Function of Cellular Phosphatidylinositol....Pages 31-47
Detection of Receptor-Linked Phosphoinositide Metabolism in Brain of Lithium-Treated Rats....Pages 49-65
Propranolol-Induced Membrane Perturbation and the Metabolism of Phosphoinositides and Arachidonoyl Diacylglycerols in the Retina....Pages 67-82
Neurotransmitter Receptor-Mediated Myo-Inositol 1-Phosphate Accumulation in Hippocampal Slices....Pages 83-90
Early Events in the Selective Cytotoxicity to Tumor Cells Induced by Liposomes Containing Plant Phosphatidylinositol....Pages 91-97
Back Matter....Pages 99-104
Front Matter....Pages 105-105
Phosphatidylinositol Synthase in Mammalian Pancreas....Pages 107-121
The Enzymology of Phosphoinositide Catabolism, with Particular Reference to Phosphatidyl-Inositol 4,5-Bisphosphate Phosphodiesterase....Pages 123-135
Subcellular Sites of Polyphosphoinositide Metabolism in Rat Liver....Pages 137-159
Loss of Phosphatidylinositol and Gain in Phosphatidate in Neutrophils Stimulated with Fmet-Leu-Phe....Pages 161-177
The De Novo Phospholipid Synthesis Effect: Occurrence, Characteristics, Underlying Mechanisms and Functional Significance in Hormone Action and Secretion....Pages 179-198
Hydrolysis of Phosphatidylinositol 4-phosphate and Phosphatidylinositol(4,5)-Bisphosphate by Specific Phosphomonoesterases in Human Erythrocytes....Pages 199-206
Drug-Induced Modifications of Phosphoinositide Metabolism....Pages 207-212
Back Matter....Pages 213-218
Front Matter....Pages 219-219
Inositol Lipid Breakdown in Receptor-Mediated Responses of Sympathetic Ganglia and Sympathetically Innervated Tissues....Pages 221-236
Hormone Effects on Phosphoinositide Metabolism in Liver....Pages 237-253
Relationship Between Vasopressin Activation of Rat Hepatocyte Glycogen Phosphorylase, Inhibition of $$C{{a}^{{{{2}^{ + }}}}} - M{{g}^{{{{2}^{ + }}}}}$$ and Phosphoinositide Breakdown....Pages 255-274
Polyphosphoinositides and Muscarinic Cholinergic and α 1 -Adrenergic Receptors in the Iris Smooth Muscle....Pages 275-298
The Phosphatidylinositol Effect in the Retina: Role of Light and Neurotransmitters....Pages 299-312
Ca 2+ -Mobilizing Agonists Stimulate a Polyphosphoinositide-Specific Phospholipase C in Rat Parotid Gland....Pages 313-320
Back Matter....Pages 329-333
Front Matter....Pages 219-219
Phosphatidylinositol Degradation is Directly Proportional to the Rate of Cell Division in Embryonic Chicken Lens Epithelia....Pages 321-327
Back Matter....Pages 329-333
Front Matter....Pages 335-335
Messages of the Phosphoinositide Effect....Pages 337-349
Inositol Trisphosphate and Calcium Mobilization....Pages 351-366
Calcium-Phosphatidylinositol Interactions in Secretory Cells and the Role of Arachidonic Acid....Pages 367-383
Calcium and Inositol Phospholipid Degradation in Signal Transduction....Pages 385-398
The Role of Phosphoprotein B-50 in Phosphoinositide Metabolism in Brain Synaptic Plasma Membranes....Pages 399-414
Purification of Protein Kinase C and Phorbol Ester Receptor Using Polyacrylamide-Immobilized Phosphatidylserine....Pages 415-422
Second Messenger Role of Inositol Trisphosphate for Mobilization of Intracellular Calcium in Liver....Pages 423-433
Back Matter....Pages 435-439
Front Matter....Pages 441-441
Mechanisms for Eicosanoid Precursor Uptake and Release by a Tissue Culture Cell Line....Pages 443-457
The Mobilization of Arachidonate and Metabolism of Phosphoinositides in Stimulated Human Platelets....Pages 459-473
The Relevance of Inositide Degradation and Protein Kinase C in Platelet Responses....Pages 475-492
Regulation of Arachidonic Acid Release for Prostaglandin Production during Parturition....Pages 493-510
Is Phosphatidylinositol Involved in the Release of Free Fatty Acids in Cerebral Ischemia?....Pages 511-527
Endogenous Phospholipid Metabolism in Stimulated Human Platelets: A Link Between Inositide Breakdown and Calcium Mobilization....Pages 529-536
Phosphatidylinositol Turnover in Madin-Darby Canine Kidney Cells: Comparison of Stimulation by A23187 and 12- O -Tetradecanoyl-Phorbol-13-Acetate....Pages 537-543
Back Matter....Pages 545-548
Front Matter....Pages 549-549
Inositol, Sorbitol and Diabetic Neuropathy....Pages 551-562
Altered Nerve Myo -Inositol Metabolism in Experimental Diabetes and Its Relationship to Nerve Function....Pages 563-582
Changes in Peripheral Nerve Polyphosphoinositide Metabolism in Experimental Diabetes: Nature and Significance....Pages 583-599
Relationship of Inositol, Phosphatidylinositol and Phosphatidic Acid in CNS Nerve Endings....Pages 601-619
Polyphosphoinositide Turnover in the Nervous System....Pages 621-635
Back Matter....Pages 643-655
Front Matter....Pages 549-549
Metabolism of Inositol-Containing Phospholipids in the Superior Cervical Ganglion of the Rat....Pages 637-642
Back Matter....Pages 643-655
Back Matter....Pages 657-698