Peroxisomes in Biology and Medicine

Front Matter....Pages I-XVIII
Front Matter....Pages 1-1
Morphogenesis of Peroxisomes in Lipid-Synthesizing Epithelia....Pages 3-17
Peroxisomes in Sebaceous Glands: Biosynthetic Role and Hormonal Regulation....Pages 18-31
Peroxisomal Alkyl-Dihydroxyacetonephosphate Synthase and a Related Enzyme in Microsomes (Microsomal Synthase) of Rat Liver....Pages 32-39
Localization of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase in Rat Liver Peroxisomes....Pages 40-52
Dolichol Metabolism and Peroxisomes....Pages 53-66
Liver Peroxisomes and Bile Acid Formation....Pages 67-77
Peroxisomes, Proliferation, and the Synthesis of Phospholipids....Pages 78-88
Evidence for a Link Between Peroxisomes and the Nonspecific Lipid Transfer Protein (Sterol Carrier Protein 2) in Rat and Human Liver....Pages 89-93
Front Matter....Pages 95-95
Comparison of Enzymes of Lipid β-Oxidation in Peroxisomes and Mitochondria....Pages 97-104
Cloning and Structural Analysis of the Genes for Peroxisomal β-Oxidation Enzymes....Pages 105-114
Immunoelectron Microscopy of Peroxisomal Enzymes; Their Substructural Association and Compartmentalization in Rat Kidney Peroxisomes....Pages 115-127
β-Oxidation Systems in Eukaryotic Microorganisms....Pages 128-140
Higher Plant Peroxisomes and Fatty Acid Degradation....Pages 141-151
Physiological Role of Peroxisomal Beta-Oxidation....Pages 152-165
Front Matter....Pages 167-167
Permeability of the Peroxisomal Membrane....Pages 169-176
Peroxisomal Properties with Potential Regulatory Implications: Selective ATP Requirement for Fatty Acid Oxidation and Membrane Protein Phosphorylation....Pages 177-188
Glyoxysomal Membrane Electron Transport Proteins....Pages 189-193
The Alkaline Lipase of the Glyoxysomal Membrane Is a Glycoprotein....Pages 194-198
A Proton Translocating ATPase Is Associated with the Peroxisomal Membrane of Yeasts....Pages 199-204
Study on Membrane Fluidity of Liver Peroxisomes....Pages 205-209
Front Matter....Pages 211-211
Peroxisomal Glycolate Metabolism and the C 2 Oxidative Photosynthetic Carbon Cycle....Pages 213-222
Peroxisomal Oxidases and Their Probable Role in Controlling Animal Metabolism....Pages 223-233
Amino Acid Metabolism in Animal Peroxisomes....Pages 234-243
Aldehyde Dehydrogenase in Mammalian Peroxisomes....Pages 244-252
Front Matter....Pages 253-253
Induction of Hepatic Peroxisome Proliferation by Xenobiotics....Pages 255-262
Phenotypic Properties of Preneoplastic and Neoplastic Hepatic Lesions Induced by Peroxisome Proliferators in Rats....Pages 263-272
The Relationship Between the Levels of Long-Chain Acyl-CoA and Clofibryl-CoA and the Induction of Peroxisomal β-Oxidation....Pages 273-278
Prevention of Peroxisomal Proliferation by Carnitine Palmitoyltransferase Inhibitors in Cultured Rat Hepatocytes and In Vivo....Pages 279-285
Use of Primary Cultures of Adult Rat Hepatocytes to Study the Mode of Action of the Peroxisome Proliferator Nafenopin....Pages 286-294
Effects of Antilipolytic Drugs on Hepatic Peroxisomes....Pages 295-303
Induction of Cytochrome P-450 and Peroxisome Proliferation in Rat Liver by Perfluorinated Octane Sulphonic Acid (PFOS)....Pages 304-308
Risks and Benefits of Agents Which Induce Hepatic Peroxisome Proliferation....Pages 309-314
Automatic Image Analysis for Morphometric Studies of Peroxisomes....Pages 315-319
Front Matter....Pages 321-321
Pathogenesis of Zellweger’s Cerebro-Hepato-Renal Syndrome and Related Peroxisome Deficiency Diseases....Pages 323-334
Observations About the Phenotype of Peroxisomal Disorders....Pages 335-340
Biochemical Analysis in Peroxisomal Disorders....Pages 341-352
Complementation Analysis of Peroxisomal Diseases by Somatic Cell Fusion....Pages 353-357
Fatty Acid Metabolism in Cultured Skin Fibroblasts from Patients with Peroxisomal Disorders: Lignoceroyl-CoA Ligase Deficiency in Childhood Adrenoleukodystrophy....Pages 358-363
Liver Peroxisomal Oxidizing Activities in Physiological and Pathological Conditions....Pages 364-373
Deficiency of Peroxisomal Alanine: Glyoxylate Aminotransferase in Primary Hyperoxaluria Type 1....Pages 374-378
Front Matter....Pages 321-321
Retrospective Immunocytochemical Demonstration of Peroxisomal Enzymes in Human Liver Biopsies Processed Conventionally for Light and Electron Microscopy....Pages 379-384
Front Matter....Pages 385-385
Introduction to the Session on Biogenesis....Pages 387-393
Biogenesis of Peroxisomes in Rat Liver and Candida Tropicalis ....Pages 394-401
Biogenesis of Rat Liver Peroxisomal Membrane Polypeptides....Pages 402-416
Biogenesis of Plant Microbodies....Pages 417-425
Biogenesis of Glycosomes (Microbodies) in the Trypanosomatidae....Pages 426-435
Metabolic Significance and Biogenesis of Microbodies in Yeasts....Pages 436-458
Back Matter....Pages 459-470