The Target Organ and the Toxic Process: Proceedings of the European Society of Toxicology Meeting Held in Strasbourg, September 17–19, 1987

Front Matter....Pages I-XIII
Front Matter....Pages 1-1
In Vitro and In Vivo Research on Phototoxic Xenobiotics: Structure-Reactivity Relationships....Pages 3-9
Photoallergy, Mechanisms and Models....Pages 10-15
Human Drug Photosensitivity: Predictive Studies in Guinea Pigs....Pages 16-25
Photomutagenicity Induced by Psoralens: Mechanism of Repair and Photomutagenicity....Pages 26-34
Photomutagenicity Induced by Psoralens: Modulation of the Photomutagenic Response in Eukaryotes....Pages 35-46
Chemical Modifiers of Photocarcinogenesis....Pages 47-51
Photogenotoxicity of Bergamot Oil in Salmonella Typhimurium TA102 and in V79 Chinese Hamster Cells: Efficiency Assessment of Filter Protective Effect....Pages 52-55
DNA Damage Caused by Laser Light Activated Hematoporphyrin Derivatives in Isolated Nuclei of Human Melanoma Cells....Pages 56-59
Systemic Photobiological Effects of Xenobiotics....Pages 60-64
Photomutagenic Effect Induced by 4,4′,6-Trimethylangelicin in Salmonella typhimurium TA 102 and Saccharomyces cerevisiae D7....Pages 65-67
Front Matter....Pages 69-69
Mechanistic Studies on the Thyroid Toxicity Induced by Certain Drugs....Pages 71-79
Comparison of the Effects of SK&F 93479 and Phenobarbitone Treatment on Thyroid Toxicity and Hepatic Thyroid Hormone Metabolising Enzymes in the Rat....Pages 80-84
Thyroid Hyperactivity Caused by Hypolipodaemic Compounds and Polychlorinated Biphenyls: The Effect of Coadministration in the Liver and Thyroid....Pages 85-92
The Effect of Sodium Bromide on Thyroid Function....Pages 93-97
Hyperplastic and Neoplastic Responses of the Thyroid Gland in Toxicological Studies....Pages 98-106
Chronic Zinc Ethylenebisdithiocarbamate Toxicity in Calves: Effects on the Thyroid and Clinicopathological Findings....Pages 107-109
Lymphocytic Thyroiditis in Beagle Dogs....Pages 110-113
Front Matter....Pages 115-115
Nephrotoxicity of Antitumoral Agents....Pages 117-124
Effect of Cadmium Ions on Na/K-ATPase Activity in a Defined Segment of the Rabbit Proximal Tubule....Pages 125-128
In Vivo and In Vitro Assessment of Vancomycin-Induced Nephrotoxicity....Pages 129-136
Front Matter....Pages 115-115
Renal Papillary Necrosis and Upper Urothelial Carcinoma....Pages 137-142
Age-Dependent Differences in Nephrotoxicity of Xenobiotics....Pages 143-150
Chronobiological Approach to Aminoglycosides....Pages 151-157
Effects of Puromycin Aminonucleoside on Ten Urinary Enzymes in Rats....Pages 158-161
Monoclonal Antibodies to Brush Border Antigens for the Early Diagnosis of Nephrotoxicity....Pages 162-165
Effects of Cisplatin and Carboplatin on Cell Cultures of Renal and Non-renal Origin....Pages 166-170
Reduction of Cisplatin Nephrotoxicity by Selenium: Does Metallothionein Play a Role?....Pages 171-174
The Relationships Between Plasma Cyclosporin Levels and Renal Tubulotoxicity Assessed by Enzymuria After Liver Transplantation....Pages 175-178
Renal Function in Lithium Treatment....Pages 179-185
In Vitro Study and Conformational Analysis of 1- N -Aminohydroxybutyryl Derivatives of Aminoglycosides in Correlation with Their Inhibitory Potency Towards Lysosomal Phospholipases....Pages 186-189
Proximal Tubule Brush Border Angiotensin Converting Enzyme Behaviour and Nephrotoxicity Due to 1,2-Dichloropropane....Pages 190-192
Effects of Subsequent Peroral or Intravenous (“Refill”) Cholegraphy on Kidney Function in Dogs....Pages 193-196
Dichlorovinylcysteine-Induced Nephrotoxicity: Role of Peroxidative Injury....Pages 197-200
In Vivo Studies on the Relationship Between Hepatic Metabolism and Toxicity of Ochratoxin A....Pages 201-204
Front Matter....Pages 205-205
Hepatic Peroxisome Proliferation: An Overview....Pages 207-216
Structure-Activity Relationships for Hepatic Peroxisome Proliferation....Pages 217-224
Influence of Drugs on Liver Mitochondria and Peroxisomes....Pages 225-232
Effects of Adipates, Phthalates, and Fibrates on Liver Enzymes and Peroxisomes in a Variety of Mammalian Species....Pages 233-239
Mechanisms of Tumor Induction by Peroxisome Proliferators....Pages 240-247
Concomitant Induction of Cytosolic Epoxide Hydrolase and Peroxisomal β-Oxidation by Hypolipidemic Compounds in Rat and Guinea Pig Liver....Pages 248-255
Front Matter....Pages 205-205
A Dicarboxylic Acid Derivative of the Hypolipidemic Peroxisome Proliferator, Tiadenol, Triggers Induction of Long-Chain Fatty Acid Metabolising Enzymes and Peroxisomal β-Oxidation....Pages 256-259
A Dicarboxylic Metabolite of Tiadenol, Bis-(carboxyethylthio)-1,10 Decane, Which Causes Hypolipidemia and Proliferation of Peroxisomes When Administered to Rodents, Is Activated to an Acyl-coenzyme A Thioester....Pages 260-264
In Vivo and In Vitro Metabolism of Di-(2-ethylhexyl) Adipate a Peroxisome Proliferator, in the Rat....Pages 265-268
Allyl Alcohol and Acrolein Toxicity in Isolated Rat Hepatocytes is Independent of Lipid Peroxidation....Pages 269-273
Di-(2-ethylhexyl) Adipate and Peroxisome Proliferation: Identification of Proximate Peroxisomal Proliferator In Vivo and In Vitro....Pages 274-277
The Effect of Ethionine on Peroxisome-Associated Enzymes....Pages 278-282
Immunoaffinity Purification and Comparison of Epoxide Hydrolases from Liver Cytosol and Peroxisomes of Untreated and Clofibrate-Treated Mice....Pages 283-287
Induction of Cytosolic and Microsomal Epoxide Hydrolases in Murine Liver by Known Peroxisome Proliferators and Structurally Related Substances....Pages 288-293
Enterohepatic Circulation of Fenofibrate Metabolites in the Rat, a Peroxisome Proliferator Responsive Species....Pages 294-296
The Effect of Clofibrate Feeding on Enzyme Activities and Mitochondrial Protein Content in Rat Liver and Renal Cortex....Pages 297-299
Anticancer Drug Toxicity in the Absence of Hypophyseal or Adrenal Secretion....Pages 300-303
Studies on Human Blood Myeloperoxidase and Peroxidase from Rat Uterus, Intestine, and Spleen....Pages 304-307
Biotransformations of γ-Picoline in the Rat....Pages 308-312
Front Matter....Pages 313-313
Enzymatic and/or Non-Enzymatic “Suicidal” Activation of Carbon Tetrachloride by Heam and Cytochrome P-450....Pages 315-317
Method for Assessment of Experimental Allergy in Guinea Pigs Adapted to Cosmetic Ingredients....Pages 318-321
Immunotoxicotherapy for Colchicine Poisoning: Toxicological and Pharmacological Features of an Experimental Model Simulating Human Poisoning....Pages 322-325
Cardiovascular Actions of Lead in Rats as Related to the Level of Chronic Exposure....Pages 326-329
Detection of DNA Damage Induced by Doxorubicin and the Effect of Glutathione....Pages 330-333
Chromosome Aberrations in Human Lymphocytes with a New Resin Composite for Aerospace Use....Pages 334-336
Testing of 2,4,5- and 2,4,6-Trimethylaniline in the Salmonella Assay, in Mammalian Cell Cultures, and in Drosophila melanogaster , and Comparison of the Results with Carcinogenicity Data....Pages 337-340
Front Matter....Pages 313-313
Base Substitution Mutations Induced by the Mycotoxin Citrinin....Pages 341-346
Toxicity and Mutagenicity of Patulin in Different Test Systems....Pages 347-351
The Combined Acute Toxicity of Lonidamine with Some Other Anticancer Agents or Acetylsalicylic Acid....Pages 352-355
Cytotoxicity of Simple Geiparvarin Analogues....Pages 356-361
Epoxide Metabolites of Opiates and Their Interaction with the Hepatic Microsomal Epoxide Hydrolase....Pages 362-365
Purification and Characterization of Acidic Glutathione S -Transferases (EC 2.5.1.18) from Rat Kidney....Pages 366-369
1,2-Dichloropropane-Induced Liver Toxicity: Clinical Data and Preliminary Studies in Rats....Pages 370-374
Induction of Hepatic Metallothionein Following Acetaminophen Administration....Pages 375-377
The Effect of Cimetidine or Phenobarbital on the Hepatotoxicity of Citalopram in Male Rats....Pages 378-380
Quantitative Morphology of Hepatocyte Nuclei in the Comparative Studies of Di(2-ethylhexyl)phthalate Effects....Pages 381-383
Organic Solvents Affect Rat Synaptosome Membrane Acetylcholinesterase and Adenosine Triphosphatase In Vitro....Pages 384-386
Effect of 2-Methyl-4-chlorophenoxyacetic Acid on Liver Catalase in Chicken Embryos....Pages 387-390
β-Cyclodextrin and Local Muscle Toxicity of Intramuscular Drug Formulations....Pages 391-393
Determination of Ethyl Loflazepate, an Anxiolytic Benzodiazepine, in Human Plasma by High-Performance Liquid Chromatography....Pages 394-397
Determination of Cocaine in Hair After Repeated Administration to Sheep....Pages 398-401
Analysis of Ethanol in Blood: A Comparison of the Abbott TD X TM Ethanol Assay with Gas Chromatography and Chemical Assays....Pages 402-404
Comparative Toxicity of Three Quinoxaline-di-N-dioxide Feed Additives in Young Pigs....Pages 405-409
Cardiotoxicity of Doxorubicin: A Histochemical and Morphometric Approach....Pages 410-412
Inhomogeneous 60 Co Whole Body Irradiation of the Göttinger Miniature Swine: A Model for the Study of Long-Term Immunomodulating Effects....Pages 413-417
Toxicological Studies with Amrinone....Pages 418-422
Front Matter....Pages 313-313
Puffing Patterns of Smokers Switching to Low-Yield Cigarettes: A Controlled Cross-over Study on Diurnal Changes in Behaviour....Pages 423-427
Effect of Pyridinium, 1 — {[(3-benzoylpyridinio) — methoxy]methyl} — 2 — [(hydroxyimino)methyl] — dichloride (HGG 12) on Various Respiratory and Circulatory Parameters of Anesthetized Guinea Pigs....Pages 428-431
Comparative Toxicity of Two Trialkylphosphorothioates to Rat Lung and the Effects of Atropine Sulphate Pretreatment....Pages 432-434
Urinary Mercury Levels and Renal Function Changes in Dentists and Dental Assistants....Pages 435-437
Comparison of the Effects of Sodium N -Benzyl-D-glucamine Dithiocarbamate and Ditripentat on the Toxicity, Excretion, and Tissue Distribution of Cadmium in Mice....Pages 438-440
Is the Noxious Hemolytic Effect of Copper a Result of Lipoperoxidation?....Pages 441-444
Effects of Cobalt, Indium, and Nickel on 7-Ethoxycoumarin- O -Deethylase in Mice....Pages 445-448
Chronic Lead Treatment and Ultrastructure of the Testis in Rats....Pages 449-452
Enzyme-Linked Immunosorbent Assay for Detection of Clostridium difficile Toxin B....Pages 453-456
Back Matter....Pages 457-462