Antimutagenesis and Anticarcinogenesis Mechanisms II

Front Matter....Pages i-xiii
Antimutagenesis Studies in Japan....Pages 1-22
Cancer Prevention: Underlying Principles and Practical Proposals....Pages 23-34
Anticlastogenic Dietary Factors Assessed in Mammalian Assays....Pages 35-43
Antigenotoxic Activity of Carotenoids in Carcinogen-Exposed Populations....Pages 45-59
Plant Antimutagens....Pages 61-78
Human Biomonitoring in Exposure to Environmental Genotoxicants....Pages 79-86
The Concept of Activity Profiles of Antimutagens....Pages 87-104
Prevention of Formation of Important Mutagens/Carcinogens in the Human Food Chain....Pages 105-118
Free Radical Reactions with DNA and Its Nucleotides....Pages 119-125
Mechanisms of Inactivation of Oxygen Radicals by Dietary Antioxidants and Their Models....Pages 127-137
Role of Dietary Antioxidants in Protection against Oxidative Damage....Pages 139-153
Inhibition of Carcinogenesis by Naturally-Occurring and Synthetic Compounds....Pages 155-166
Newly Recognized Anticarcinogenic Fatty Acids....Pages 167-170
Caloric Restriction in Experimental Carcinogenesis....Pages 171-182
Carcinogenicity and Modification of Carcinogenic Response by Antioxidants....Pages 183-194
Inhibition of Tumor Promotion by DL-α-Difluoromethylornithine, A Specific Irreversible Inhibitor of Ornithine Decarboxylase....Pages 195-204
New Antitumor Promoters: (-)-Epigallocatechin Gallate and Sarcophytols A and B....Pages 205-212
Chemoprevention of Mammary Cancer by Retinoids....Pages 213-224
Suppression of Tumor Promotion by Inhibitors of Poly(ADP)Ribose Formation....Pages 225-232
Antimutagenic Activity of Vitamins in Cultured Mammalian Cells....Pages 233-256
Microcell-Mediated Chromosome Transfer: A Strategy for Studying the Genetics and Molecular Pathology of Human Hereditary Diseases with Abnormal Responses to DNA Damage....Pages 257-267
Genetic Analyses of Cellular Functions Required for UV Mutagenesis in Escherichia Coli ....Pages 269-275
Position of a Single Acetylaminofluorene Adduct Within a Mutational Hot Spot is Critical for the Related Mutagenic Event....Pages 277-287
Fidelity of Animal Cell DNA Polymerases α and δ and of a Human DNA Replication Complex....Pages 289-297
Molecular Mechanisms of Replicational Fidelity in Escherichia Coli ....Pages 299-308
Permanent Conversion of NIH3T3 Cells Transformed by Activated c-Ha- ras , c-Ki- ras , N- ras , or c- raf , and of Human Pancreatic Adenocarcinoma Containing Activated c-Ki- ras to Apparently Normal Cells by Treatment with the Antibiotic Azatyrosine....Pages 309-312
Oncogenes of Stomach Cancers....Pages 313-320
Oncogenic Potential and Normal Function of the Proto-Oncogenes Encoding Protein-Tyrosine Kinases....Pages 321-339
Inhibition of the Genotoxicity of 3-Amino-1-Methyl-5 H - Pyrido[4,3- b ]Indole (Trp-P-2) in Drosophila by Chlorophyll....Pages 341-344
Inhibition of Tobacco-Specific Nitrosamine 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK)-Induced Lung Tumors and DNA Methylation in F344 Rats and A/J Mice by Phenethyl Isothiocyanate....Pages 345-350
Proteolytic Activation of UmuD and MucA Proteins for SOS Mutagenesis....Pages 351-354
Analysis of Bleomycin-Resistant DNA Synthesis in Cells from an Inherited Human Disorder, Ataxia Telangiectasia....Pages 355-359
Tumor Dose-Response Studies with Aflatoxin B 1 and the Ambivalent Modulator Indole-3-Carbinol: Inhibitory Versus Promotional Potency....Pages 361-365
Antimutagenesis in Yeast by Sodium Chloride, Potassium Chloride, and Sodium Saccharin....Pages 367-371
The Use of Drosophila as an in VIVO System to Study Modifiers of Chemical Mutagenesis....Pages 373-377
The Mouse Mutant, “Wasted”: Tissue-Specific Radiation Sensitivity and Hematopoietic Cell Lineages....Pages 379-383
Antimutagenic Effects of Tumor Promoters—Co-Mutagenic Effects of Co-Carcinogens....Pages 385-388
Antimutagenic Effects of Dimethyl Sulfoxide on Metabolism and Genotoxicity of Benzene in Vivo....Pages 389-393
Possible Antitumor Promoter in the Glandular Stomach: Calcium Chloride....Pages 395-400
Reversion of Transformed NIH 3T3 Cells to Flat Cells by Inhibitors of Poly(ADP-ribose) Polymerase....Pages 401-405
Inactivation of Mutagenic Heterocyclic and Aryl Amines by Linoleic Acid 13-Monohydroperoxide and Methemoglobin....Pages 407-410
Establishment of a Highly Reproducible Transformation Assay of a Ras -Transfected Balb 3T3 Clone by Treatment with Promoters....Pages 411-416
Antimutagenic Effect of umuD Mutant Plasmids: Isolation and Characterization of umuD Mutants Reduced in their Ability to Promote UV Mutagenesis in Escherichia Coli ....Pages 417-421
Antitumor-Promoting Activity of Sesquiterpene Isolated from an Herbal Spice....Pages 423-427
Inhibitory Effects of Chlorogenic Acid, Reserpine, Polyprenoic Acid (E-5166), or Coffee on Hepatocarcinogenesis in Rats and Hamsters....Pages 429-440
Antimutagenic Structure Modification of Quinoline: Fluorine-Substitution at Position-3....Pages 441-446
Mutagenicity and Antimutagenicity of Thai Medicinal Plants....Pages 447-452
Influence of Potential Antioxidants on Free-Radical Damage of Lymphocytes....Pages 453-456
Specificity of Antimutagens against Chemical Mutagens in Microbial Systems....Pages 457-460
Classification of Mechanisms of Inhibitors of Mutagenesis and Carcinogenesis....Pages 461-462
Antimutagenic Effects of Chlorophyllin....Pages 463-468
Back Matter....Pages 469-485