Biological Effects of Dietary Restriction

Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Terminology and Methods in Dietary Restriction Research....Pages 3-11
Nutritional Adequacy in Dietary Restriction....Pages 12-15
Significance of Dietary Contaminants in Diet Restriction Studies....Pages 16-24
Front Matter....Pages 25-25
Dietary Restriction and Toxicological Endpoints: An Historical Overview....Pages 27-41
Effects of Caloric Restriction on Aflatoxin B 1 Metabolism and DNA Modification in Fischer 344 Rats....Pages 42-54
Dietary and Caloric Restriction: Its Effect on Cellular Proliferation in Selected Mouse Tissues....Pages 55-64
The Impact of Calorie Restriction on Mammary Cancer Development in an Experimental Model....Pages 65-72
Pathological Endpoints in Dietary Restricted Rodents—Fischer 344 Rats and B6C3F 1 Mice....Pages 73-86
Effects of Dietary Restriction on Age-Associated Pathological Changes in Fischer 344 Rats....Pages 87-98
Influence of Diet Restriction on Toxicity and Hormonal Status in Chemically Treated Mice....Pages 99-111
Front Matter....Pages 113-113
Physiological Consequences of Dietary Restriction: An Overview....Pages 115-122
Aging, Dietary Restriction, and Glucocorticoids: A Critical Review of the Glucocorticoid Hypothesis....Pages 123-139
The Effect of Dietary Restriction on the Endocrine Control of Reproduction....Pages 140-146
Chronic Energy Intake Restriction: Influence on Longevity, Autoimmunity, Immunodeficiency, and Cancer in Autoimmune-Prone Mice....Pages 147-156
Behavioral and Neurobiological Effects of Dietary Restriction in Aged Rodents....Pages 157-171
Prevention in the Decline of Membrane-Associated Functions in Immune Cells During Aging by Food Restriction....Pages 172-182
Front Matter....Pages 183-183
Caloric Restriction and Its Effects on Molecular Parameters, Especially DNA Repair....Pages 185-190
Prevention of Free Radical Damage by Food Restriction....Pages 191-197
Modifications in Regulation of Intermediary Metabolism by Caloric Restriction in Rodents....Pages 198-206
Effects of Long-Term Caloric Restriction on Hepatic Drug-Metabolizing Enzyme Activities in the Fischer 344 Rat....Pages 207-216
Front Matter....Pages 183-183
Urinary Biomarkers of Oxidative DNA-Base Damage and Human Caloric Intake....Pages 217-225
Front Matter....Pages 227-227
Models for Investigating How Dietary Restriction Retards Aging: The Adaptation Hypothesis....Pages 229-237
Aging, Dietary Restriction, and Cancer in a Germ-Free Animal Model....Pages 238-244
Chronic Caloric Restriction in Old Female Mice: Changes in the Circadian Rhythms of Physiological and Behavioral Variables....Pages 245-263
Genes Regulate Effects of Dietary Restriction....Pages 264-286
1200-Rat Biosure Study: Design and Overview of Results....Pages 287-304
Primate Models for Dietary Restriction Research....Pages 305-317
Front Matter....Pages 319-319
Impact of Dietary Restriction on Bioassays and Recommendations for Future Research: Panel Discussion....Pages 321-336
Back Matter....Pages 337-354