Biological Signal Transduction

Front Matter....Pages I-XI
The Nicotinic Acetylcholine Receptor: A Member of the Superfamily of Ligand-Gated Ion Channels....Pages 1-16
Epidermal Growth Factor Receptor Autophosphorylation Is Not Required for Normal Mitogenic or Transforming Signal Generation....Pages 17-29
The Epidermal Growth Factor Receptor: Receptor Dimerization and Signal Transduction....Pages 31-44
Dimerization Activates the Epidermal Growth Factor Receptor Tyrosine Kinase....Pages 45-58
Insulin-Related Peptides and Their Receptor(s) in the Mollusc, Lymnaea Stagnalis ....Pages 59-72
Hepatic Vasopressin Receptor: A Key Receptor of Phosphoinositide Metabolism....Pages 73-84
Gene Targeting by Homologous Recombination as a Tool to Study the Biophysical Role of the Interferon-γ Signalling Pathway....Pages 85-99
Expression of Novel Cloned Rat Pituitary Receptors in Mammalian Cells....Pages 101-113
Cellular Localization of Seven Transmembrane Domain Receptor mRNA’S by In-Situ Hybridization....Pages 115-129
The T Cell Activation Molecule CD27 Is a Member of the Nerve Growth Factor Receptor Gene Family....Pages 131-145
Membrane Receptor Clustering as a Cellular Stimulus — The Mast Cell Case....Pages 147-162
G Protein-Coupled Receptors: Structural Basis of Selective Signaling....Pages 163-177
Hormone Receptor-Effector Coupling in Prolactin Producing Pituitary Cell Lines (GH Cells)....Pages 179-191
Effect of Aging on the ß-Adrenergic Signal Transduction System in Rat Kidney, Lung, and Mononuclear Leukocytes....Pages 193-206
The Transducin Cycle in the Phototransduction Cascade....Pages 207-220
Expression of Two Isoforms of the Guanine Nucleotide Binding Protein,G o , IN NG108–15 Neuroglioma Cells....Pages 221-235
Mechanisms Underlying Hormonal Modification of Dopamine Receptor Sensitivity....Pages 237-251
Phosphorylation of the Growth-Factor Activatable Na + /H + Antiporter: A Mechanism of Regulation....Pages 253-269
Overexpression of Protein Kinase C α in Swiss/3T3 Cells Reduces The Number of Both High and Low Affinity of the Epidermal Growth Factor Receptors....Pages 271-281
Characterization of Protein Kinase C Isoforms in a Small Cell Lung Carcinoma Cell Line: Regulation of PKC ε and its Catalytic Fragment....Pages 283-299
The Human Type I cGMP-Dependent Protein Kinase Gene....Pages 301-308
Control of Cellular Activity by Protein Phosphorylation-Dephosphorylation: Phosphorylase Kinase from Bovine Stomach Smooth Muscle....Pages 309-320
Properties of Phosphoinositides in Membranes....Pages 321-330
Glycosyl-Phosphatidylinositol Membrane Anchors....Pages 331-348
Cell Adhesion in Morphogenesis....Pages 349-365
Inositol Phosphate Metabolism and Function....Pages 367-373
Inositol 1,4,5-Triphosphate and Inositol 1,3,4,5-Tetrakisphosphate: Functions, Metabolism and Interconversion....Pages 375-388
Histamine H 1 -Receptor-Mediated Breakdown of Inositol Phospholipids in Primary Neuronal Cultures....Pages 389-401
Intracellular Ca 2+ Homeostasis: Receptor-Activated Ca 2+ Channels and Intracellular Ca 2+ Pools....Pages 403-419
Multiple sources of sn -1,2-diacylglycerol in mitogen-stimulated Swiss 3T3 cells; evidence for activation of phosphoinositidase C and PtdChophospholipase D....Pages 421-434
Phorbol Esters and Muscarinic Receptor Agonists Activate Phospholipase D in Heart and Brain....Pages 435-446
Development of a Single Cell Ca 2+ Imaging System to Study the Role of PKC Substrate B-50 in Neurotransmitter Release and Neurite Outgrowth....Pages 447-458
Regulated Exocytosis as a Paradigm of Biological Signal Transduction....Pages 459-473
Mannose 6-phosphate Receptors and their Role in Protein Sorting along the Pathway to Lysosomes....Pages 475-482
Protein Sorting in Endosomes....Pages 483-494
Note to the Addendum....Pages 495-495
Guanylate Cyclase in Signal Transduction of Dictyostelium Discoideum....Pages 497-509
Epidermal Growth Factor Mediated Signal Transduction in Rat Hepatocytes....Pages 511-525
Back Matter....Pages 527-543