Red Blood Cell Aging

Front Matter....Pages i-x
Front Matter....Pages 1-1
Synthesis of the Transferrin Receptor in Peripheral Sheep Reticulocytes: Evidence for Incomplete Oligosaccharide Processing....Pages 3-13
The Loss of Enzyme Activity from Erythroid Cells During Maturation....Pages 15-27
Role and Mechanism of Hexokinase Decay During Reticulocyte Maturation and Cell Aging....Pages 29-35
Behaviour of Glucose-6-Phosphate Dehydrogenase during Erythroid Maturation....Pages 37-43
Front Matter....Pages 45-45
KCl Cotransport in HbAA and HbSS Red Cells: Activation by Intracellular Acidity and Disappearance During Maturation....Pages 47-57
Conformational Changes and Oxidation of Membrane Proteins in Senescent Human Erythrocytes....Pages 59-73
Selective Binding of Met-Hemoglobin to Erythrocytic Membrane: A Possible Involvement in Red Blood Cell Aging....Pages 75-84
Diabetes Mellitus and Red Blood Cell Aging: A Structural and Functional Study....Pages 85-89
Front Matter....Pages 91-91
Characterization of Senescent Red Cells from the Rabbit....Pages 93-103
The Mechanism of Enzyme Decline in the Red Blood Cell During the “In Vivo” Aging Process....Pages 105-113
The Relationship Between the Blood Oxygen Transport and the Human Red Cell Aging Process....Pages 115-123
Red Cell Metabolism, Normal and Abnormal Implications for Red Cell Aging....Pages 125-137
Significance and Relevance of NAD Synthesis in Human Erythrocyte Life Span....Pages 139-146
Front Matter....Pages 147-147
Hypotheses on the Physiological Role of Enzymatic Protein Methyl Esterification Using Human Erythrocytes as a Model System....Pages 149-160
Heterogeneity of Guanine Nucleotide Binding Proteins in Human Red Blood Cell Membranes....Pages 161-171
Role of Hemoglobin Denaturation and Band 3 Clustering in Initiating Red Cell Removal....Pages 173-183
A Potential, Intracellular Trigger for Removal of Senescent Erythrocyte: Hemoglobin with Methionine Beta (55) D6 Oxidized to the Sulfoxide Derivative....Pages 185-190
Ubiquitin-Mediated Processes in Erythroid Cell Maturation....Pages 191-205
Acylphosphatase and Calcium Transport Across Erythrocyte Membrane....Pages 207-215
Free Radicals Promote “In Vitro” a Different Intracellular Decay of Rabbit Reticulocyte and Erythrocyte Glycolytic Enzymes....Pages 217-223
Front Matter....Pages 225-225
Clinical Utility of Fractionating Erythrocytes into “Percoll” Density Gradients....Pages 227-238
The Role of Red Cell Aging in the Diagnosis of Glycolytic Enzyme Defects....Pages 239-249
Molecular Characterization of Plasma Membrane Calcium Pump Isoforms....Pages 251-261
Human Erythrocyte D-Aspartyl/L-Isoaspartyl Methyltransferases: Enzymes that Recognize Age-Damaged Proteins....Pages 263-276
The Isoenzymes of Mammalian Hexokinase: Tissue Specificity and In Vivo Decline....Pages 277-284
Phagocytosis of Phenylhydrazine Oxidized and G-6-PD Deficient Red Blood Cells: The Role of Sugars and Cell-Bound Immunoglobulins....Pages 285-300
Front Matter....Pages 301-301
Molecular Mapping of the Active Site of an Aging Antigen....Pages 303-316
Recognition Signals for Phagocytic Removal of Favic Malaria-Infected and Sickled Erythrocytes....Pages 317-327
Inhibition by Carbohydrates and Monoclonal Anticomplement Receptor Type 1, on Interactions between Senescent Human Red Blood Cells and Monocytic Macrophagic Cells....Pages 329-337
In Vitro Sequestration of Erythrocytes from Hosts of Various Ages....Pages 339-350
A New Monoclonal Antibody to an Age Sensitive Band 3 Transmembrane Segment....Pages 351-356
Characterization of Antibody that Binds In Vivo to Normal Human Red Blood Cells....Pages 357-365
Opsonic Potential of C3b-Anti-Band 3 Complexes when Generated on Senescent and Oxidatively Stressed Red Cells or in Fluid Phase....Pages 367-376
Back Matter....Pages 377-383