Chromosome Segregation and Aneuploidy

Front Matter....Pages I-XVII
Chromosome Segregation and Aneuploidy....Pages 1-12
Structure of the mammalian centromere....Pages 13-29
Properties of CENP-B and Its Target Sequence in a Satellite DNA....Pages 31-43
The Minor Satellite of Mouse and the Centromere....Pages 45-62
Centromere Organization in Man and Mouse....Pages 63-74
New tools for the study of chromosome segregation and aneuploidy at the molecular level....Pages 75-86
Premature Centromere Division and Other Centromeric Misbehaviour....Pages 87-92
Genetic Approaches for Identifying Kinetochore Components in Saccharomyces Cerevisiae ....Pages 93-110
Cell Cycle Regulation of Centromere Function in Saccharomyces Cerevisiae ....Pages 111-120
Sensing DNA Damage: a Role for Chromosome Communication in Aneuploidy Induction....Pages 121-131
The acquisition and association of TG 1–3 single-strand tails during replication of Saccharomyces telomeres....Pages 133-141
Transposition as a Mechanism for Maintaining Telomere Length in Drosophila....Pages 143-149
Molecular Features of Heterochromatin Condensation....Pages 151-164
RCC1-Ran-RanGAP Signal for Initiation of Mitosis....Pages 165-172
Implications of Cell Cycle Disturbances for Meiotic Aneuploidy: Studies on a Mouse Model System....Pages 173-182
Morphogenesis of the Mitotic and Meiotic Spindle: Conclusions Obtained From one System are not Necessarily Applicable to the Other....Pages 183-197
A Genetic Analysis of Microtubule Assembly and Function in Yeast....Pages 199-209
The Events and Regulation of Anaphase Onset....Pages 211-224
Microtubule Converging Centers — Implications for Microtubule Dynamics in Higher Plants....Pages 225-239
Development of Kinetochores During Early Mitosis in HeLa Cells and the Stability of a Trilaminar Kinetochore Structure....Pages 241-255
Are topoisomerases required for Mammalian Chromosome Segregation?....Pages 257-267
Possible Targets for the Aneugenic Activity of Alkylating Agents....Pages 269-282
The Relationship Between Chemically-Induced Meiotic Delay and Aneuploidy in Mouse Oocytes and Zygotes....Pages 283-296
Correlation Between Induction of Meiotic Delay and Aneuploidy in Male Mouse Germ Cells....Pages 297-308
Analysis of Micronuclei and Microtubule Arrangement to Identify Aneuploidy-Inducing Agents in Cultured Mammalian Cells....Pages 309-319
Effects of Antitopoisomerase Drugs on Chromosome Recombination and Segregation in Grasshopper....Pages 321-336
Disruption of Centromere Function by 2-Aminopurine....Pages 337-351
Induction of Mitotic Aneuploidy in Lower Eukaryotes....Pages 353-361
In vivo assays for detection and evaluation of aneugens....Pages 363-376
Multicolor Fluorescence In Situ Hybridization with Centromeric DNA Probes as a New Approach to Distinguish Chromosome Breakage from Aneuploidy in Interphase Cells and Micronuclei....Pages 377-390
The detection, definition and regulation of aneugenic chemicals....Pages 391-415
Back Matter....Pages 417-430