Molecular Biology of Mitochondrial Transport Systems

Front Matter....Pages I-XII
Molecular Studies of the Mitochondrial Uncoupling Protein....Pages 1-9
Structure-Function Relationship in the Uncoupling Protein of Brown Adipose Tissue....Pages 11-18
The Gating and Coupling Function of Mitochondrial, H + ATP Synthase. Role of F o and F 1 Subunits....Pages 19-39
Extension of the Mitochondrial Transporter Family....Pages 41-53
The Tricarboxylate Carrier....Pages 55-65
The Mitochondrial Pyruvate Carrier: The Mechanism of Substrate Binding....Pages 67-79
Membrane Topology of the ADP/ATP Carrier from Mitochondria....Pages 81-97
The Use of Ligand Binding Techniques to Identify Transport Proteins: The Characterization of the [125I]-Iodophenylarsine Oxide Receptor in Rat Mitochondrial Membranes....Pages 99-116
Channel Properties of Mitochondrial Carriers....Pages 117-129
A Minimal Kinetic Model of the Activity of the 107 pS Channel of the Inner Membrane of Mitochondria....Pages 131-136
A Channel Model to Explain Regulation of the Mitochondrial Inner Membrane Anion Channel (IMAC)....Pages 137-151
The Mitochondrial Permeabilization Pore....Pages 153-168
Mitochondrial Channels: An Integrated View....Pages 169-198
Purification and Patch Clamp Analysis of Two Mitochondrial Channels....Pages 199-208
The Mitochondrial Outer Membrane Contains at Least Two Distinct Channels....Pages 209-219
ATP-Sensitive K + Channel in Rat Liver Mitochondria: Functional Characteristics....Pages 221-228
Probing for the Voltage Sensor in a Mitochondrial Channel, VDAC, Using Site-Directed Mutagenesis....Pages 229-248
Insights Into the Structure of the Mitochondrial Channel, VDAC, Provided by Electron Microscopy....Pages 249-263
Experimental Supports to a Sixteen-Strands Model of Transmembrane Arrangement of Mitochondrial Porin and Preliminary Results Concerning a Multigene Family in Drosophila melanogaster Related to Human Mitochondrial Porin....Pages 265-280
Structure and Function of the VDAC Ion Channel....Pages 281-296
The Function of the Mitochondrial Outer Membrane Pore in the Regulation of Peripheral Kinases and Energy Metabolism....Pages 297-311
Coordinated Regulation of Cerebral Glycolytic and Oxidative Metabolism Mediated by Mitochondrially Bound Hexokinase....Pages 313-325
Influence of Macromolecules on the Permeability of Porin Pores and Dynamic Compartmentation of Adenine Nucleotides in the Mitochondrial Intermembrane Space....Pages 327-340
Restrictions of Metabolite Permeation Through the Outer Mitochondrial Membrane of Porin-Deficient Yeast Mutant....Pages 341-356
Role of Porin-Kinase Interactions in Disease....Pages 357-377
Genes Encoding Human VDAC Proteins: Identification of Multiple Isoforms, Expression in Yeast and Chromosomal Localization....Pages 379-388
“Porin 31HL” in the Plasmalemma of Human Cells: A VDAC Discussed as Part of a Chloride Channel Complex in Normal and Cystic Fibrosis B-Lymphocyte Cell Lines....Pages 389-405
Back Matter....Pages 406-412