The Cell Cycle: Regulators, Targets, and Clinical Applications

Front Matter....Pages i-xi
Front Matter....Pages 1-1
Protein Phosphorylation and the Regulation of Key Events in Oocyte and Egg Cell Cycles....Pages 3-15
Control of G1 Progression by Mammalian D-Type Cyclins....Pages 17-23
Phosphorylation in the Regulation of Protein Phosphatases....Pages 25-32
Positive and Negative Regulation of Cell Cycle Progression by Serine/Threonine Protein Phosphatases....Pages 33-40
Effects of Phosphatase Inhibitors on Mammalian p34 cdc2 Kinase Activities....Pages 41-49
The Meiotic Role of twine , A Drosophila Homologue of cdc25 ....Pages 51-57
Front Matter....Pages 59-59
Extracellular Signal-Regulated Protein Kinases (ERKS) 1, 2, and 3....Pages 61-66
Cell Cycle Traverse and Growth Arrest Control in Senescent Human Fibroblasts....Pages 67-78
Cellular Senescence and the Cell Cycle....Pages 79-89
Cell Cycle Targets of Viral Oncoproteins....Pages 91-97
A GTPase Cycle Coupled to the Cell Cycle....Pages 99-110
Sphingolipids Metabolites: A New Class of Second Messengers in the Regulation of Cell Growth....Pages 111-119
Front Matter....Pages 121-121
Histone Gene Transcription During the Cell Cycle....Pages 123-125
G1-S Regulatory Promoter Elements and their Interacting Transcription Factors....Pages 127-139
Regulation of Thymidylate Synthase Gene Expression in Growth-Stimulated Cells....Pages 141-147
The Role of the Transcription Factor E2F in the Growth Regulation of DHFR....Pages 149-154
Activation of the Heat Shock Transcription Factor During G 1 ....Pages 155-161
DNA Damage and Cell Cycle Regulation in S. Cerevisiae ....Pages 163-166
Preferential Repair of Cisplatin Adducts in the Human DHFR Gene During G 1 Phase Assayed with T4 DNA Polymerase....Pages 167-171
Front Matter....Pages 173-173
Direct Inhibition of p107 WEE1 by the Nim 1/CDR 1 Kinase....Pages 175-184
Front Matter....Pages 173-173
A Human Phosphotyrosine Phosphatase Associated with M Phase-Promoting Factor....Pages 185-188
The Localisation of Human Cyclins and CDKS in the Cell Cycle....Pages 189-195
Regulation of Nuclear Envelope Assembly and Disassembly by ARF and other GTP-Binding Proteins....Pages 197-202
Possible Role of the Multi Catalytic Proteinase (Proteasome) in Regulating of the Cell Cycle....Pages 203-209
Cytostellin: A Nuclear Protein that Redistributes to Peripheral Cytoskeletal Locations During Mitosis and G1....Pages 211-221
Evidence for M-Phase-Specific Modification of a Gap Junction Protein....Pages 223-228
Analysis of Centrosome Replication Events in Mammalian Cells....Pages 229-235
Requirements for Microtubule Polymerization and a Calcium Surge for the Metaphase-to-Interphase Transition in Mature Mouse Oocytes....Pages 237-243
Front Matter....Pages 245-245
Mos Proto-Oncogene and Cell Cycle Regulation....Pages 247-249
Altered Regulation of Cell Cycle Genes and Proteins in Senescent Human Diploid Fibroblasts....Pages 251-262
Cell Proliferation as a Biomarker of Age and Development....Pages 263-269
Heat Shock Genes and Cell Cycle Regulation During Early Mammalian Development....Pages 271-281
Expression of G1 Cyclins During Early Development of Zebrafish Embryos....Pages 283-289
Apoptosis: Definition, Roles and Regulation....Pages 291-299
Front Matter....Pages 301-301
Molecules of Deregulated Cell Cycle Control in Cancer....Pages 303-309
The Two Amino Terminal Transforming Functions of the SV40 Large T-Antigen are Required to Overcome P53 Mediated Growth Arrest....Pages 311-317
Down Regulation of Candidate Tumor Suppressor Genes in Breast Cancer....Pages 319-322
Expression and Regulation of Cyclin Genes in Breast Cancer Cells....Pages 323-329
Genotoxin-Induced Apoptosis: Implications for Carcinogenesis....Pages 331-340
Monitoring and Repair of DNA Damage During G 2 in Relation To Carcinogenesis....Pages 341-346
Front Matter....Pages 301-301
Cell Cycle Regulation in Normal Versus Leukemic T Cells....Pages 347-357
Cells Undergoing HIV Envelope-Mediated Programmed Degeneration Accumulate in G2/M Phase....Pages 359-366
Front Matter....Pages 367-367
The Involvement of the Cell Cycle in Apoptosis....Pages 369-378
Cell Cycle Regulation and the Chemosensitivity of Cancer Cells....Pages 379-388
Multiple Cell Cycle Checkpoint Override and its Potential for Binary Tumor Therapy....Pages 389-396
Radiation Induced G2 Delay and Mitotic Cyclin Expression....Pages 397-403
Cyclin B Degradation as a Target of Antiproliferative Drug Action....Pages 405-410
Clinical Relevance of DNA Ploidy and Cell Cycle Phases in Transitional Cell Carcinoma of the Renal Pelvis and Ureter: A Study by Means of Static DNA-Cytophotometry....Pages 411-419
Back Matter....Pages 421-430