Vasopressin and Oxytocin: Molecular, Cellular, and Clinical Advances

Front Matter....Pages i-xvi
Vasopressin Receptors....Pages 1-13
Cell-Specific Gene Expression in Oxytocin and Vasopressin Magnocellular Neurons....Pages 15-27
Hypothalamic Transcription Factors and the Regulation of the Hypothalamo-Neurohypophysial System....Pages 29-37
POU Domain Factors in Neural Development....Pages 39-53
Local Protein Synthesis in Magnocellular Dendrites....Pages 55-57
Vasopressin Gene Expression in Rat Choroid Plexus....Pages 59-65
Electrophysiological Distinctions Between Oxytocin and Vasopressin Neurons in the Supraoptic Nucleus....Pages 67-77
Mechanisms of Neuroendocrine Cell Excitability....Pages 79-95
Properties of the Transient K + Current in Acutely Isolated Supraoptic Neurons from Adult Rat....Pages 97-106
GABA B Receptors and Supraoptic Neuronal Activity....Pages 107-115
Local Glutamatergic and GABAergic Synaptic Circuits and Metabotropic Glutamate Receptors in the Hypothalamic Paraventricular and Supraoptic Nuclei....Pages 117-121
Progesterone Regulates Hypothalamic Oxytocin mRNA Levels Through Gamma Aminobutyric Acid....Pages 123-125
Differential Effects of the Neurosteroid Pregnenolone Sulphate on Oxytocin and Vasopressin Neurones in Vitro ....Pages 127-128
Regulation of Vasopressin Release by Ionotropic Glutamate Receptor Agonists....Pages 129-130
Role of N -Methyl-D-Aspartate (NMDA) Receptors in Vasopressin and Oxytocin Responses to Emotional Stimuli....Pages 131-134
Electrophysiological Studies of Oxytocin Neurons in Organotypic Slice Cultures....Pages 135-145
Inhibitory Actions of Nociceptin (Orphanin FQ) on Rat Supraoptic Nucleus Oxytocin and Vasopressin Neurones in Vitro....Pages 147-151
New Aspects of Firing Pattern Autocontrol in Oxytocin and Vasopressin Neurones....Pages 153-162
Intrahypothalamic Vasopressin Release....Pages 163-173
Differential Central and Peripheral Release of Vasopressin and Oxytocin in Response to Swim Stress in Rats....Pages 175-177
Pregnancy and Aging....Pages 179-181
Effect of Age and Testosterone on the Vasopressin Response to Dehydration in F344BNF1 Male Rats....Pages 183-185
Evidence for Nitric Oxide (NO) Actions Throughout the Forebrain Osmoresponsive Circuit....Pages 187-189
Gaseous Neurotransmitter Modulation of Vasopressin and Oxytocin Release....Pages 191-192
Membrane Excitability in the Neurohypophysis....Pages 193-200
Vasopressin’s Depolarizing Action on Neonatal Rat Spinal Lateral Horn Neurons May Involve Multiple Conductances....Pages 201-210
Vasopressin Action in the Mammalian Cerebral Cortex....Pages 211-213
Oxytocin, Vasopressin, and the Neuroendocrine Basis of Pair Bond Formation....Pages 215-224
Central Oxytocin Neurotransmission....Pages 225-230
Targeted Reduction of Oxytocin Expression Provides Insights into its Physiological Roles....Pages 231-240
Phenotypic Expression of an Oxytocin Peptide Null Mutation in Mice....Pages 241-243
Antiproliferative Effect of Oxytocin through Specific Oxytocin Receptors in Human Neuroblastoma and Astrocytoma Cell Lines....Pages 245-246
Phosphorylation of Proteins Induced in a Murine Pre-T Cell Line by Neurohypophysial Peptides....Pages 247-249
Molecular Pharmacology of Human Vasopressin Receptors....Pages 251-276
Molecular Mechanisms Regulating the Effects of Oxytocin on Myometrial Intracellular Calcium....Pages 277-286
Genomic and Non-Genomic Mechanisms of Oxytocin Receptor Regulation....Pages 287-295
The Molecular Basis of Oxytocin and Oxytocin Receptor Gene Expression in Reproductive Tissues....Pages 297-306
Transcriptional Regulation of the Oxytocin Receptor Gene....Pages 307-315
Female Reproduction in Mice Lacking the Prostaglandin F Receptor....Pages 317-321
Expression of the Oxytocin Receptor and Oxytocin Gene in Human Oocytes and Preimplantation Embryos....Pages 323-324
Vasopressin Regulates Adrenal Functions by Acting through Different Vasopressin Receptor Subtypes....Pages 325-334
All Three Vasopressin Receptor Sub-Types are Expressed by Small-Cell Carcinoma....Pages 335-338
Processing and Ligand-Induced Modifications of the V2 Vasopressin Receptor....Pages 339-346
Molecular Aspects of Vasopressin Receptor Function....Pages 347-358
Mapping Peptide Antagonist Binding Sites of the Human V1a and V2 Vasopressin Receptors....Pages 359-361
Structure/Function Studies on Receptors for Vasopressin and Oxytocin....Pages 363-365
Identification of a Constitutively Active Mutant of the Human Oxytocin Receptor....Pages 367-369
Identification of Neurohypophysial Hormone Receptor Domains Involved in Ligand Binding and G Protein Coupling....Pages 371-385
Mutations in the Vasopressin V2 Receptor and Aquaporin-2 Genes in Twelve Families with Congenital Nephrogenic Diabetes Insipidus....Pages 387-390
Functional Study of Two V2 Vasopressin Mutant Receptors Related to NDI....Pages 391-393
Studies of Renal Aquaporin-2 Expression during Renal Escape from Vasopressin-Induced Antidiuresis....Pages 395-406
Prompt and Sustained Regulation of Aquaporin-2 by Arginine Vasopressin in Collecting Duct Cells and Clinical Implication of Urinary Excretion of Aquaporin-2....Pages 407-414
Recent Advances in the Understanding of Water Metabolism in Heart Failure....Pages 415-426
Nonpeptide Antagonists for Vasopressin Receptors....Pages 427-438
VPA-985, a Nonpeptide Orally Active and Selective Vasopressin V 2 Receptor Antagonist....Pages 439-443
Effects of Chronic AVP V2R Blockade in Congestive Heart Failure in Sheep....Pages 445-446
Vasopressin Induces Opposite Changes in Blood Flow in the Skin and the Muscular Circulation....Pages 447-449
Discovery of Novel Selective Hypotensive Vasopressin Peptides....Pages 451-453
Safety, Tolerability, and Pharmacokinetics of SR 49059, a V1A Vasopressin Receptor Antagonist, After Repeated Oral Administration in Healthy Volunteers....Pages 455-465
Evidence for an Involvement of Vasopressin in Mechanism of Primary Dysmenorrhea and Effect of the Non-Peptide Vasopressin V 1a Receptor Antagonist, SR 49059, on the Uterus of Non-Pregnant Women....Pages 467-472
Progress in the Development of Oxytocin Antagonists for Use in Preterm Labor....Pages 473-479
Back Matter....Pages 481-483