Potassium Channels in Cardiovascular Biology

Front Matter....Pages i-xlv
Front Matter....Pages 1-1
Evolution of Potassium Channel Proteins....Pages 3-16
Three-Dimensional Structure of the K + Channel Pore: Basis for Ion Selectivity and Permeability....Pages 17-34
Molecular Biology of Voltage-Gated K + Channels....Pages 35-48
Molecular Biology of High-Conductance, Ca 2+ -Activated Potassium Channels....Pages 49-70
Molecular Biology of Inward Rectifier and ATP-Sensitive Potassium Channels....Pages 71-88
Front Matter....Pages 89-89
Design and Use of Antibodies for Mapping K + Channel Expression in the Cardiovascular System....Pages 91-102
Molecular Methods for Evaluation of K + Channel Expression and Distribution in the Heart....Pages 103-118
Concepts for Patch-Clamp Recording of Whole-Cell and Single-Channel K + Currents in Cardiac and Vascular Myocytes....Pages 119-142
The Patch-Clamp Technique for Measurement of K + Channels in Xenopus Oocytes and Mammalian Expression Systems....Pages 143-161
Heteromultimer Formation in Native K + Channels....Pages 163-175
Use of Transgenic and Gene-Targeted Mice to Study K + Channel Function in the Cardiovascular System....Pages 177-191
Front Matter....Pages 193-193
Pharmacology of Voltage-Gated K + Channels....Pages 195-217
Pharmacology of High-Conductance, Ca 2+ -Activated Potassium Channels....Pages 219-234
Pharmacology of Small-Conductance, Calcium-Activated K + Channels....Pages 235-256
Molecular Pharmacology of ATP-Sensitive K + Channels: How and Why?....Pages 257-277
Front Matter....Pages 279-279
Overview: Molecular Physiology of Cardiac Potassium Channels....Pages 281-296
Molecular Mechanisms Controlling Functional Voltage-Gated K + Channel Diversity and Expression in the Mammalian Heart....Pages 297-335
Voltage-Gated Potassium Channels in the Myocardium....Pages 337-362
Inward Rectifying and ATP-Sensitive K + Channels in the Ventricular Myocardium....Pages 363-386
Cholinergic and Adrenergic Modulation of Cardiac K + Channels....Pages 387-426
Front Matter....Pages 279-279
Cardiac K + Channel Expression and Function at Birth and in the Neonate....Pages 427-439
Front Matter....Pages 441-441
Overview: Physiological Role of K + Channels in the Regulation of Vascular Tone....Pages 443-455
Modulation of Vascular K + Channels by Extracellular Messengers....Pages 457-483
Delayed Rectifier K + Channels of Vascular Smooth Muscle: Characterization, Function, and Regulation by Phosphorylation....Pages 485-503
Potassium Channels in the Circulation of Skeletal Muscle....Pages 505-522
Regulation of Cerebral Artery Diameter by Potassium Channels....Pages 523-542
The Role of Potassium Channels in the Control of the Pulmonary Circulation....Pages 543-570
Potassium Channels in the Renal Circulation....Pages 571-589
Potassium Channels in the Coronary Circulation....Pages 591-615
Vascular K + Channel Expression and Function at Birth and in the Neonate....Pages 617-636
Front Matter....Pages 637-637
Overview: Potassium Channels in Vascular Endothelial Cells....Pages 639-650
Single-Channel Properties of Ca 2+ -Activated K + Channels in the Vascular Endothelium....Pages 651-666
Endothelial Cell K + Channels, Membrane Potential and the Release of Vasoactive Factors from the Vascular Endothelium....Pages 667-689
Activation of Vascular Smooth Muscle K + Channels by Endothelium-Derived Factors....Pages 691-723
Front Matter....Pages 725-725
Overview: The Role of Potassium Channels in Cardiac Arrhythmias....Pages 727-752
The Molecular Basis of the Long QT Syndrome....Pages 753-772
Altered K + Channel Expression in the Hypertrophied and Failing Heart....Pages 773-783
Role of ATP-Sensitive K + Channels in Cardiac Preconditioning....Pages 785-800
Therapeutic Potential of ATP-Sensitive K + Channel Openers in Cardiac Ischemia....Pages 801-818
Front Matter....Pages 819-819
Altered Expression and Function of Kv Channels in Primary Pulmonary Hypertension....Pages 821-836
Front Matter....Pages 819-819
Anorectic Drugs and the Vasculature....Pages 837-852
Induction of Ca 2+ -Activated K + Channel Expression during Systemic Hypertension: Protection against Pathological Vasoconstriction....Pages 853-867
Antisense Approaches and the Modulation of Potassium Channel Function in the Cardiovascular System....Pages 869-886
Back Matter....Pages 887-899