The Many Faces of Osteoarthritis

Front Matter....Pages i-xl
Front Matter....Pages 1-4
Type IIA procollagen NH 2 -propeptide functions as an antagonist of bone morphogenetic proteins....Pages 5-16
Genetics and osteoarthritis....Pages 17-25
Metabolic differences between knee and ankle....Pages 27-29
Prevention of lower limb osteoarthritis: Data from the Johns Hopkins Precursors Study....Pages 31-37
The inheritance of hip osteoarthritis in Iceland....Pages 39-44
Dynamics of matrix loss in the spontaneous osteoarthritic mouse strain STR-1N....Pages 45-49
Back Matter....Pages 51-60
Front Matter....Pages 61-66
Identification and characterization of human cell populations capable of forming stable hyaline cartilage in vivo ....Pages 67-76
Osteogenic protein-1 promotes proteoglycan synthesis and inhibits cartilage degeneration mediated by fibronectinfragments....Pages 77-80
Osteogenic protein-1 and its receptors in human articular cartilage....Pages 81-89
The transcription factors L-Sox5 and Sox6 are essential for cartilage formation....Pages 91-100
Amelogenin peptides have unique milieu-dependent roles in morphogenic path determination....Pages 101-105
Back Matter....Pages 107-112
Front Matter....Pages 113-116
Electron microscope studies of collagen fibril formation in cornea, skin and tendon: Implications for collagen fibril assembly and structure in other tissues....Pages 117-129
Hyaluronics and aggrecanics....Pages 131-146
Lectin domains in hyaluronan-binding proteoglycans....Pages 147-150
The matrilins: A novel family of extracellular adaptor proteins....Pages 151-158
Superficial zone protein (SZP) is an abundant glycoprotein in human synovial fluid with lubricating properties....Pages 159-161
Establishment of in vitro cell culture models for the investigation of the pathogenesis of cartilage diseases....Pages 163-166
Back Matter....Pages 167-174
Front Matter....Pages 175-178
Role of hyaluronan in regulating joint fluid flow....Pages 179-188
Elastoviscous hyaluronan in the synovium in health and disease....Pages 189-206
The covalent complex formation of hyaluronan with heavy chains of inter-α-trypsin inhibitor family is important for its functions....Pages 207-212
Back Matter....Pages 231-236
Front Matter....Pages 175-178
 In vivo investigation of hyaluronan and hyaluronan synthase-2 function during cartilage and joint development....Pages 213-218
CD44 and cartilage matrix stabilization....Pages 219-230
Back Matter....Pages 231-236
Front Matter....Pages 237-239
Metalloproteinases and osteoarthritis....Pages 241-246
Age-dependent changes in some physico-chemical properties of human articular cartilage....Pages 247-252
The role of the bone/cartilage interface in osteoarthritis....Pages 253-259
Dualistic role of TGFβ in osteoarthritis cartilage destruction and osteophyte formation....Pages 261-265
Back Matter....Pages 267-270
Front Matter....Pages 271-274
Collagen cross-links as markers of bone and cartilage degradation....Pages 275-284
Markers of joint tissue turnover in osteoarthritis....Pages 285-292
Gene expression profiling by the cDNA array technology: Molecular portraying of chondrocytes....Pages 293-296
Clinical evaluation of markers for osteoarthritis....Pages 297-302
Joint degradation in rapidly destructive and hypertrophic osteoarthritis of the hip....Pages 303-308
Differential gene trap: A new strategy for identifying genes regulated during cartilage differentiation....Pages 309-311
Back Matter....Pages 313-320
Front Matter....Pages 321-328
Imaging cartilage changes in osteoarthritis....Pages 329-350
Diffraction enhanced x-ray imaging of articular cartilage....Pages 351-354
Bone changes in osteoarthritis (OA)....Pages 355-362
Radiographic joint space width (JSW): A marker of disease progression in OA of the hip....Pages 363-367
Small proteoglycans in knee and ankle cartilage....Pages 369-372
Back Matter....Pages 373-379
Front Matter....Pages 381-385
Fixed charge density and cartilage biomechanics....Pages 387-395
Influence of tissue shear deformation on chondrocyte biosynthesis and matrix nano-electromechanics....Pages 397-408
The biomechanical faces of articular cartilage in growth, aging,and osteoarthritis....Pages 409-422
Back Matter....Pages 433-438
Front Matter....Pages 381-385
Cartilage tissue engineering using a new self-assembling peptide gel scaffold....Pages 423-428
Differential effects of IL-1β on human knee and ankle chondrocytes....Pages 429-432
Back Matter....Pages 433-438
Front Matter....Pages 439-442
Dynamic function and imaging in the analysis of osteoarthritis at the knee....Pages 443-452
Linking the biology of osteoarthritis to locomotion mechanics....Pages 453-460
Movement patterns of individuals with good potential to dynamically stabilize their knees after acute ACL rupture....Pages 461-463
Neuromuscular control of the ACL deficient knee: Implications for the development of osteoarthritis....Pages 465-472
Back Matter....Pages 473-479
Back Matter....Pages 481-495