Pathophysiology of Cardiovascular Disease

Front Matter....Pages i-xix
Front Matter....Pages 1-1
Septic Cardiomyopathy....Pages 3-21
Mitochondrial Function—A Limiting Factor in Heart Failure?....Pages 23-33
Myosin Heavy Chain Isoforms Modulate Motor Function of Cardiac Myosin by Changing Crossbridge Kinetics....Pages 35-49
Role of Reactive Oxygen Species in the Regulation of Cardiac Myocyte Phenotype....Pages 51-57
Functional Significance of Ryanodine Receptor-Mediated Calcium Leaks in Sarcoplasmic Reticulum Membranes....Pages 59-80
Cell-Cell and Cell-Extracellular Matrix Interactions in Cardiomyopathy....Pages 81-86
Role of the Phosphoinositide 3-Kinase Pathway in Cardiac Hypertrophy....Pages 87-100
Role of Ras/GTPase and Calcium/Calmodulin-dependent Protein Kinase II in the Signal Transduction Mechanisms Involved in Hyperthermic Preconditioning....Pages 101-107
Interactions of the Cyclic AMP and Nitric Oxide Pathways in Cardiac Fibroblasts....Pages 109-123
Do Humoral and Mechanical Stimulation of Cardiomyocytes Share Common Transduction Pathways?....Pages 125-136
Differential Inhibition by the Phosphatase Inhibitor Cantharidin of the Anti-adrenergic Effect of Endothelin-1 and Carbachol in the Canine Ventricular Myocardium....Pages 137-151
Factors Involved in Self and Drug-Induced Spontaneous Ventricular Defibrillation: Intra and Inter Species Variations....Pages 153-166
Cardiac ATP-Sensitive Potassium Channel: A Bi-Functional Channel/Enzyme Multimer....Pages 167-180
Measurement of Cytosolic pH Simultaneouly with Isometric Tension in Canine Trabeculae....Pages 181-199
Front Matter....Pages 201-201
Redox Regulation of Ischemic Heart Disease....Pages 203-221
Cell Biology of Acute Reperfusion Injury....Pages 223-228
Reactive Oxygen Species, Na + /H + Exchange and Ca 2+ Overload During Myocardial Ischemia/Reperfusion Injury: The Paradox Explained?....Pages 229-238
Calcium Signalling During Acute Myocardial Ischemia: New Insights From Optical Mapping Techniques....Pages 239-255
Effects of Ischemia on Cardiomyocyte Connexin-43 Distribution and Phosphorylation Studied in in vivo and in vitro Models....Pages 257-268
Temperature Dependence of Ischemic Preconditioning....Pages 269-276
Front Matter....Pages 201-201
Mechanism of Cardioprotective Effect of Remote Aortic Preconditioning....Pages 277-285
Inhibition of Degranulation of Resident Cardiac Mast Cells May Prevent Ischaemia and Reperfusion-Induced Myocardial Injury....Pages 287-301
Mechanisms of Cardioprotection against Ischemia Reperfusion Injury....Pages 303-326
Front Matter....Pages 327-327
Modulation of Arachidonic Acid Metabolism by Phorbol 12-Myristate 13-Acetate in Monocytes and Myocytes....Pages 329-340
Endothelium-Derived Hyperpolarizing Factor(s). Does it Exist and What Role Does it Play in the Regulation of Blood Flow?....Pages 341-348
Cytokinesis in Smooth Muscle....Pages 349-360
ADP-Ribosylation and the Cardiovascular System....Pages 361-382
Influence of the Myocardium Contractile State in the Coronary Venous Flow Deviation Phenomenon....Pages 383-391
Natriuretic Peptides and Endothelin in Aortic Stenosis and Heart Transplantation....Pages 393-404
Activation of Mitogen-Activated Protein Kinases and Protein Kinase B/Akt Signaling by Oxidative Stress in Vascular Smooth Muscle Cells: Involvement in Vascular Pathophysiology....Pages 405-416
Preconditioning and Myocardial Angiogenesis....Pages 417-438
The Arachidonic Acid Cascade: Thromboxane A 2 Antagonism and Synthetase Inhibition in Experimental Myocardial Infarction....Pages 439-469
Front Matter....Pages 471-471
Receptors and Channels of Nuclear Envelope Membranes as a New Target for Drug Action....Pages 473-483
Smad Cofactors/Corepressors in the Fibrosed Post-MI Heart: Possible Therapeutic Targets....Pages 485-511
Phytoestrogens and Cardiovascular Disorders....Pages 513-524
Non-Conventional Long-Lasting Cardioprotection Induced by Chronic Exposure to Ambient Heat....Pages 525-533
Fetal and Neonatal Cardiomyocyte Transplantation for the Treatment of Myocardial Infarction....Pages 535-544
Cellular Cardiomyoplasty: The Role of Bone Marrow Stromal Cells in Myocardial Tissue Regeneration....Pages 545-554
Xenotransplantation: An Overview....Pages 555-575
Assessment of Myocardial Injury Using Magnetic Resonance Imaging....Pages 577-595
Front Matter....Pages 471-471
Magnetic Resonance in the Assessment and Development of Surgical Strategies for Protecting the Brain During Cardiovascular Surgery....Pages 597-617
Heart Failure Recovery with Mechanical Circulatory Support....Pages 619-631
Back Matter....Pages 633-648