Lysophospholipid Receptors: Signaling and Biochemistry

دسته بندی: بیوشیمی
ویرایش:  
 
سری:  
ISBN (شابک) : 9780470569054, 9781118531426 
ناشر: John Wiley & Sons, Inc. 
سال نشر: 2013 
تعداد صفحات: 788 
زبان: English 
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) 
حجم فایل: 15 مگابایت 

قیمت کتاب (تومان) : 52,000

The study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports?ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems?have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling.

Lysophospholipid Receptors is divided into three sections:

• Receptors and other possible effectors
• Enzymes
• Physiology and pathophysiology

Within each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics.

Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field.

Content:
Chapter 1 Lysophosphatidic Acid (LPA) Receptor Signaling (pages 1–39): Hope Mirendil, Mu?En Lin and Jerold Chun
Chapter 2 Sphingosine 1?Phosphate (S1P) Receptors (pages 41–60): Bongnam Jung and Timothy Hla
Chapter 3 Global Gene Expression Program of Lysophosphatidic Acid (LPA)?Stimulated Fibroblasts (pages 61–69): Catelijne Stortelers and Wouter H. Moolenaar
Chapter 4 Identification of Direct Intracellular Targets of Sphingosine 1?Phosphate (S1P) (pages 71–83): Nitai C. Hait, Sheldon Milstien and Sarah Spiegel
Chapter 5 Lysophospholipid Receptor Signaling Platforms: The Receptor Tyrosine Kinase–G Protein?Coupled Receptor Signaling Complex (pages 85–102): Nigel J. Pyne and Susan Pyne
Chapter 6 Autotaxin: A Unique Ecto?Type Pyrophosphodiesterase with Diverse Functions (pages 103–119): Hiroshi Yukiura and Junken Aoki
Chapter 7 Studies on Autotaxin Signaling in Endocytic Vesicle Biogenesis and Embryonic Development Using Whole Embryo Culture and Electroporation (pages 121–136): Masayuki Masu, Seiichi Koike, Takuya Okada and Kazuko Keino?Masu
Chapter 8 Standardization and Quantification of Lysophosphatidic Acid Compounds by Normal?Phase and Reversed?Phase Chromatography–Tandem Mass Spectrometry (pages 137–151): Jeff D. Moore, Shengrong Li, David S. Myers, Stephen B. Milne, H. Alex Brown and Walter A. Shaw
Chapter 9 Sphingosine Kinases: Biochemistry, Regulation, and Roles (pages 153–183): Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham and Stuart M. Pitson
Chapter 10 Functional and Physiological Roles of Sphingosine 1?Phosphate Transporters (pages 185–200): Atsuo Kawahara and Tsuyoshi Nishi
Chapter 11 Lipid Phosphate Phosphatases and Signaling by Lysophospholipid Receptors (pages 201–227): Ganesh Venkatraman and David N. Brindley
Chapter 12 Lipid Phosphate Phosphatases: Recent Progress and Assay Methods (pages 229–263): Andrew J. Morris, Susan S. Smyth, Abdel K. Salous and Andrew D. Renault
Chapter 13 Lysophosphatidic Acid (LPA) Signaling and Cardiovascular Pathology (pages 265–281): Susan S. Smyth, Anping Dong, Jessica Wheeler, Manikandan Panchatcharam and Andrew J. Morris
Chapter 14 Sphingosine 1?Phosphate (S1P) Signaling in Cardiovascular Physiology and Disease (pages 283–312): Bodo Levkau
Chapter 15 Sphingosine 1?Phosphate (S1P) Signaling and the Vasculature (pages 313–347): Christian Waeber
Chapter 16 Regulation of the Nuclear Hormone Receptor Ppar? by Endogenous Lysophosphatidic Acids (LPAS) (pages 349–372): Ryoko Tsukahara, Tamotsu Tsukahara and Gabor Tigyi
Chapter 17 Mechanisms and Models for Elucidating the Cardiac Effects of Sphingosine 1?Phosphate (S1P) (pages 373–397): Shigeki Miyamoto, Sunny Yang Xiang, Nicole H. Purcell and Joan Heller Brown
Chapter 18 Neural Effects of Lysophosphatidic Acid (LPA) Signaling (pages 399–418): Nobuyuki Fukushima
Chapter 19 Widespread Expression of Sphingosine Kinases and Sphingosine 1?Phosphate (S1P) Lyase Suggests Diverse Functions in the Vertebrate Nervous System (pages 419–432): H. Meng and V. M. Lee
Chapter 20 Lysophosphatidic Acid and Neuropathic Pain: Demyelination and LPA Biosynthesis (pages 433–449): Hiroshi Ueda
Chapter 21 Role of Lysophosphatidic Acid (LPA) in Behavioral Processes: Implications for Psychiatric Disorders (pages 451–473): Guillermo Estivill?Torrus, Luis Javier Santin, Carmen Pedraza, Estela Castilla?Ortega and Fernando Rodriguez de Fonseca
Chapter 22 Sphingosine 1?Phosphate (S1P) Signaling and Lymphocyte Egress (pages 475–488): Alejandra Mendoza, Lauren A. Pitt and Susan R. Schwab
Chapter 23 Biology Revealed by Sphingosine 1?Phosphate (S1P) Receptor Gene?Altered Mice (pages 489–506): Maria L. Allende, Mari Kono, Aikaterini Alexaki, Christina Giannouli, Jiman Kang, Catherine C. Theisen, Eleanor L. Koerner and Richard L. Proia
Chapter 24 Role of Lysophosphatidic Acid (LPA) in the Intestine (pages 507–527): C. Chris Yun and Peijian He
Chapter 25 Lysophospholipid Signaling in Female and Male Reproductive Systems (pages 529–567): Xiaoqin Ye
Chapter 26 The Gonads and their Magic Bullet, Lysophosphatidic Acid: Physiological and Toxicological Functions of Lysophosphatidic Acid (LPA) In Female and Male Reproductive Systems (pages 569–585): Lygia Therese Budnik, Barbel Brunswig?Spickenheier and Dieter Muller
Chapter 27 Lysophospholipid Regulation of Lung Fibrosis (pages 587–607): Barry S. Shea and Andrew M. Tager
Chapter 28 Lysophosphatidic Acid (LPA) Signaling and Bone (pages 609–625): Jean Pierre Salles, Sara Laurencin?Dalicieux, Francoise Conte?Auriol, Fabienne Briand?Mesange and Isabelle Gennero
Chapter 29 Lysophosphatidic Acid (LPA) Signaling and Bone Cancer (pages 627–640): Olivier Peyruchaud, Marion David, Timothy L. Macdonald and Kevin R. Lynch
Chapter 30 Understanding the Functions of Lysophosphatidic Acid Receptors in Cancer (pages 641–659): Nattapon Panupinthu and Gordon B. Mills
Chapter 31 Lysophosphatidic Acid Receptors in Cancer (pages 661–679): Abir Mukherjee, Jinhua Wu, Yongling Gong and Xianjun Fang
Chapter 32 LPA Receptor Subtypes LPA1 and LPA2 as Potential Drug Targets (pages 681–708): Gretchen Bain and T. Jon Seiders
Chapter 33 Clinical Introduction of Lysophosphatidic Acid (LPA) and Autotaxin Assays (pages 709–735): Yutaka Yatomi, Koji Igarashi, Kazuhiro Nakamura, Ryunosuke Ohkawa, Akiko Masuda, Akiko Suzuki, Tatsuya Kishimoto, Hitoshi Ikeda and Junken Aoki
Chapter 34 Antibodies to Bioactive Lysophospholipids (pages 737–751): Roger A. Sabbadini, Jonathan M. Wojciak, Kelli Moreno, James S. Swaney and Barbara Visentin