Textbook of Hepatology: From Basic Science to Clinical Practice, Third Edition

Previously the Oxford Textbook of Clinical Hepatology, this two-volume textbook is now with Blackwell Publishing. It covers basic, clinical and translational science (converting basic science discoveries into the practical applications to benefit people).

Edited by ten leading experts in the liver and biliary tract and their diseases, along with outstanding contributions from over 200 international clinicians, this text has global references, evidence and extensive subject matter – giving you the best science and clinical practice discussed by the best authors.

It includes unique sections on:

• Symptoms and signs in liver disease
  
• Industrial diseases affecting the liver
  
• The effects of diseases of other systems on the liver
  
• The effects of liver diseases on other systems

It’s bigger and more extensive than other books and discusses new areas in more depth such as stem cells, genetics, genomics, proteomics, transplantation, mathematics and much more.

Plus, it comes with a fully searchable CD ROM of the entire content.

Click here to view a sample chapter on the liver and coagulationContent:
Chapter 1.1 Macroscopic Anatomy of the Liver (pages 1–8): Jean H.D. Fasel, Holger Bourquain, Heinz?Otto Peitgen and Pietro E. Majno
Chapter 1.2 Liver and Biliary Tract Histology (pages 9–19): Paulette Bioulac?Sage, Brigitte Le Bail and Charles Balabaud
Chapter 1.3 Ultrastructure of the Hepatocyte (pages 20–28): Zahida Khan, James M. Crawford and Donna B. Stolz
Chapter 1.4 Liver Sinusoidal Endothelial Cells (pages 29–35): David Semela and Vijay H. Shah
Chapter 1.5 Kupffer Cells (pages 36–42): Hartmut Jaeschke
Chapter 1.6 The Hepatic Stellate Cell (pages 43–51): Massimo Pinzani
Chapter 1.7 Biliary Epithelial Cells (pages 52–57): Jean?Francois Dufour
Chapter 1.8 Hepatic Stem Cells (pages 58–64): Tania Roskams
Chapter 1.9 Embryology of the Liver and Intrahepatic Biliary Tract (pages 65–71): Frederic P. Lemaigre
Chapter 2.1 Hepatic Circulation (pages 73–88): Christophe Bureau, Jean?Marie Peron, Jean?Pierre Vinel, Yoshiya Ito, Robert S. McCuskey, Glen A. Laine and Charles S. Cox
Chapter 2.2 Functions of the Liver (pages 89–128): Paulo Renato, A. V. Correa, Michael H. Nathanson, Allan W. Wolkoff, Phyllis M. Novikoff, Sundararajah Thevananther, Saul J. Karpen, Ronald P.J.Oude Elferink, Gerhard P. Puschel and Bruno Stieger
Chapter 2.3 Metabolism (pages 129–249): Guenther Boden, Erez F. Scapa, Keishi Kanno, David E. Cohen, Margaret E. Brosnan, John T. Brosnan, Dominique Pessayre, Namita Roy?Chowdhury, Yang Lu, Jayanta Roy?Chowdhury, Peter L.M. Jansen, Klaas Nico Faber, Dieter Haussinger, Vishwanath R. Lingappa, Jose C. Fernandez?Checa, Carmen Garcia?Ruiz, Herve Puy, Jean?Charles Deybach, Masataka Okuno, Rie Matsushima?Nishiwaki, Soichi Kojima, Kyle E. Brown, George J. Brewer, Edward D. Harris, Fred K. Askari, Brent A. Neuschwander?Tetri, Chris Liddle and Catherine A.M. Stedman
Chapter 2.4 Synthetic Function (pages 250–273): Richard A. Weisiger, Maria T. DeSancho, Stephen M. Pastores and Rebecca G. Wells
Chapter 2.5 Regulation of the Liver Cell Mass (pages 274–289): Nisar P. Malek, K. Lenhard Rudolph and Anna Mae Diehl
Chapter 2.6 Excretion (pages 290–311): Martin Wagner, Michael Trauner, Mayank Bhandari and James Toouli
Chapter 2.7 Immunology of the Liver (pages 312–331): Tom Luedde, Christian Trautwein, Wajahat Z. Mehal, Alvin B. Imaeda and Wajahat Z. Mehal
Chapter 3.1 Hepatocyte Apoptosis and Necrosis (pages 333–347): Henning Schulze?Bergkamen, Marcus Schuchmann and Peter R. Galle
Chapter 3.2 Ischaemia?Reperfusion Injury to the Liver (pages 348–355): Nazia Selzner and Pierre A. Clavien
Chapter 3.3 Genetics and Liver Diseases (pages 356–383): Hongjin Huang, Ramsey Cheung, Peter T. Donaldson and Frank Lammert
Chapter 3.4 Cellular Cholestasis (pages 384–390): Stefano Fiorucci
Chapter 3.5 Oncogenes and Tumour Suppressor Genes (pages 391–397): Dipankar Chattopadhyay and Helen Reeves
Chapter 3.6 Genomics, Gene Arrays and Proteomics in the Study of Liver Disease (pages 398–420): Geoffrey W. McCaughan, Nicholas A. Shackel, Rohan Williams, Devanshi Seth, Paul S. Haber and Mark D. Gorrell
Chapter 4.1 Histological Features (pages 421–432): Valeer J. Desmet, Tania Roskams and Miguel Bruguera
Chapter 4.2 Classifications, Scoring Systems and Morphometry in Liver Pathology (pages 433–440): Pierre Bedossa and Valerie Paradis
Chapter 5.1 Signs and Symptoms of Liver Disease (pages 441–450): Jurg Reichen
Chapter 5.2 Biochemical Investigations in the Management of Liver Disease (pages 451–467): Igino Rigato, J. Donald Ostrow and Claudio Tiribelli
Chapter 5.3 Hepatic Removal Kinetics: Importance for Quantitative Measurements of Liver Function (pages 468–478): Susanne Keiding and Michael Sorensen
Chapter 5.4 Immunological Investigations in Liver Diseases (pages 479–488): Elmar Jaeckel and Michael P. Manns
Chapter 5.5 Biopsy and Laparoscopy (pages 489–499): Arthur Zimmermann
Chapter 5.6 Imaging of the Liver (pages 500–548): Luigi Bolondi, Valeria Camaggi, Fabio Piscaglia, Daniel T. Cohen, Dushyant V. Sahani, Christoforos Stoupis, Sanjeeva P. Kalva, Dushyant V. Sahani, Alan J. Wigg and James Toouli
Chapter 5.7 Interventional Radiology in Hepatobiliary Diseases (pages 549–560): Jose Ignacio Bilbao Jaureguizar, Concepcio Bru, Joan Falco Fages and Lluis Donoso
Chapter 5.8 Positron Emission Tomography of the Liver (pages 561–566): Michael Sorensen and Susanne Keiding
Chapter 5.9 Splanchnic Haemodynamic Investigations (pages 567–571): Didier Lebrec and Richard Moreau
Chapter 5.10 The Cochrane Hepatobiliary Group (pages 572–579): Christian Gluud
Chapter 6.1 The Evolution of Cirrhosis (pages 581–589): John P. Iredale and I. Neil Guha
Chapter 6.2 Cellular and Molecular Pathobiology of Liver Fibrosis and its Pharmacological Intervention (pages 590–603): Scott L. Friedman
Chapter 6.3 Clinical and Diagnostic Aspects of Cirrhosis (pages 604–619): I. Neil Guha and John P. Iredale
Chapter 7.1 Anatomy of the Portal Venous System in Portal Hypertension (pages 621–629): J. Michael Henderson
Chapter 7.2 Pathogenesis of Portal Hypertension (pages 630–639): Roberto J. Groszmann and Juan G. Abraldes
Chapter 7.3 Clinical Manifestations and Management of Bleeding Episodes in Cirrhotics (pages 640–657): Jaime Bosch, Juan G. Abraldes and Juan Carlos Garcia?Pagan
Chapter 7.4 Haemodynamic Assessment of Portal Hypertension (pages 658–665): Juan Carlos Garcia?Pagan, Juan Turnes and Jaime Bosch
Chapter 7.5 Pathogenesis, Diagnosis and Treatment of Ascites in Cirrhosis (pages 666–710): Vicente Arroyo, Carlos Terra and Luis Ruiz?del?Arbol
Chapter 7.6 Hepatorenal Syndrome (pages 711–719): Pere Gines and Monica Guevara
Chapter 7.7 Pulmonary Complications of Portal Hypertension (pages 720–727): Michael J. Krowka
Chapter 7.8 Hepatic Encephalopathy (pages 728–760): J. Michael Henderson
Chapter 7.9 Bacterial Infections in Portal Hypertension (pages 761–770): Javier Fernandez and Miguel Navasa
Chapter 7.10 Hypersplenism (pages 771–778): P. Aiden McCormick
Chapter 8.1 Congenital Conditions (pages 779–809): Jean?Pierre Benhamou, Valerie Vilgrain, Valerie Vilgrain, Valerie Vilgrain, Valerie Vilgrain, Valerie Vilgrain, Jean?Pierre Benhamou, Jean?Pierre Benhamou and Jean?Francois Cadranel
Chapter 8.2 Acquired Conditions (pages 810–817): Jean?Francois Cadranel
Chapter 9.1 Viral Hepatitis (pages 819–956): Mario Rizzetto and Fabien Zoulim
Chapter 9.2 Systemic Virosis Producing Hepatitis (pages 957–973): Alberto Biglino and Mario Rizzetto
Chapter 9.3 Human Immunodeficiency Virus and the Liver (pages 974–987): Vincent Soriano, Pablo Barreiro, Javier Garcia?Samaniego, Luz Martin?Carbonero and Marina Nunez
Chapter 9.4 Exotic Virus Infections of the Liver (pages 988–998): Pierre E. Rollin, Thomas G. Ksiazek, Alberto Queiroz Farias and Flair Jose Carrilho
Chapter 10.1 Bacterial, Rickettsial and Spirochaetal Infections (pages 999–1010): Jose M. Sanchez?Tapias
Chapter 10.2 Fungal Infections Affecting the Liver (pages 1011–1019): Roderick J. Hay
Chapter 10.3 Protozoal Infections Affecting the Liver (pages 1020–1039): David Kershenobich, Guillermo Robles Diaz, Juan Miguel Abdo, Montse Renom, Pedro L. Alonso and Manuel Corachan
Chapter 10.4 Helminthiasis (pages 1040–1067): Flair Carrilho, Pedro Paulo Chieffi, Luiz Caetano Da Silva, S. Bresson?Hadni, G.A. Mantion, J.P Miguet, D.A. Vuitton, Marcelo Simao Ferreira and Edna Strauss
Chapter 11.1 Primary Biliary Cirrhosis (pages 1069–1088): E. Jenny Heathcote and Piotr Milkiewicz
Chapter 11.2 Autoimmune Hepatitis (pages 1089–1102): Diego Vergani and Giorgina Mieli?Vergani
Chapter 11.3 Sclerosing Cholangitis (pages 1103–1110): Konstantinos N. Lazaridis and Nicholas F. LaRusso
Chapter 11.4 Vanishing Bile Duct Syndrome (pages 1111–1119): Frank Grunhage and Tilman Sauerbruch
Chapter 11.5 Overlap Syndromes (pages 1120–1126): Ulrich Beuers
Chapter 12.1 Epidemiological Aspects of Alcoholic Liver Disease (pages 1127–1134): Juan Caballeria
Chapter 12.2 Ethanol Metabolism and Pathogenesis of Alcoholic Liver Injury (pages 1135–1147): Stephen F. Stewart and Chris P. Day
Chapter 12.3 Pathology of Alcoholic Liver Disease (pages 1148–1156): Elie Serge Zafrani
Chapter 12.4 Alcoholic Liver Disease: Natural History, Diagnosis, Clinical Features, Evaluation, Prognosis and Management (pages 1157–1178): Laurent Spahr and Antoine Hadengue
Chapter 12.5 Management of the Alcoholic Patient, Including Alcoholism and Extrahepatic Manifestations (pages 1179–1191): Georges?Philippe Pageaux and Pascal Perney
Chapter 13 Non?Alcoholic Fatty Liver and Non?Alcoholic Steatohepatitis (pages 1193–1208): Geoffrey C. Farrell
Chapter 14.1 Drug?Induced Liver Injury (pages 1209–1268): Dominique Pessayre and Dominique Larrey
Chapter 14.2 Toxic Liver Injury (pages 1269–1276): Basuki Gunawan and Neil Kaplowitz
Chapter 14.3 Hepatic Injury Due to Physical Agents (pages 1277–1280): Bernhard H. Lauterburg and Haithem Chtioui
Chapter 14.4 Hepatic Toxicity Induced by Herbal Medicines (pages 1281–1288): Felix Stickel and Detlef Schuppan
Chapter 15 Acute Liver Failure and Related Syndromes (pages 1289–1312): Francois Durand and Jacques Bernuau
Chapter 16.1 Wilson's Disease (pages 1313–1322): Michael Schilsky
Chapter 16.2 Haemochromatosis (pages 1323–1329): Antonello Pietrangelo
Chapter 16.3 Alpha?1?Antitrypsin Deficiency and Related Disorders (pages 1330–1335): Jeffrey H. Teckman
Chapter 16.4 The Liver in Cystic Fibrosis (pages 1336–1342): Andrew P. Feranchak
Chapter 16.5 Human Hereditary Porphyrias (pages 1343–1351): Elisabeth Irene Minder and Xiaoye Schneider?Yin
Chapter 16.6 Hyperbilirubinaemia (pages 1352–1359): Peter L.M. Jansen
Chapter 16.7 The Liver in Intracellular and Extracellular Lipidosis (pages 1360–1369): Dominique P. Germain
Chapter 16.8 Glycogen Storage Diseases (pages 1370–1376): Philippe Labrune
Chapter 16.9 Mitochondriopathies (pages 1377–1382): Pierre Rustin
Chapter 16.10 Genetic Cholestatic Diseases (pages 1383–1388): Ronald P.J. Oude Elferink
Chapter 17.1 Hepatic Artery Diseases (pages 1389–1394): Peter C. Hayes
Chapter 17.2 Obstruction of the Portal Vein (pages 1395–1402): Juan Carlos Garcia?Pagan, Manuel Hernandez?Guerra and Jaime Bosch
Chapter 17.3 Disorders of the Hepatic Veins and Hepatic Sinusoids (pages 1403–1417): Dominique?Charles Valla
Chapter 17.4 Congenital Vascular Malformations (pages 1418–1423): Guadalupe Garcia?Tsao
Chapter 18.1 Benign Hepatic Tumours (pages 1425–1436): Jean?Pierre Benhamou, Massimo Colombo and Riccardo Lencioni
Chapter 18.2 Malignant Tumours (pages 1437–1463): Jordi Bruix, Alejandro Forner, Maria Varela, Carmen Ayuso, Josep Maria Llovet, Miguel Bruguera and Juan Rodes
Chapter 18.3 Metastatic Tumours (pages 1464–1478): Masamichi Kojiro, Antoni Castells and Humphrey J.F. Hodgson
Chapter 19.1 Intrahepatic Cholestasis (pages 1479–1500): Olivier Chazouilleres and Chantal Housset
Chapter 19.2 Extrahepatic Biliary Obstruction: Systemic Effects, Diagnosis and Management (pages 1501–1517): Michelle C. Gallagher and James S. Dooley
Chapter 19.3 Gallstone Disease (pages 1518–1540): Frank Lammert, Franz?Ludwig Dumoulin and Tilman Sauerbruch
Chapter 19.4 Cholangitis and Biliary Tract Infections (pages 1541–1549): Ulrich Beuers
Chapter 19.5 Haemobilia (pages 1550–1560): Antonio Lacy and Nader K. Francis
Chapter 19.6 Biliary Dyskinesia (pages 1561–1572): C. Ritchie Chalmers and Giles J. Toogood
Chapter 19.7 Benign Biliary Tumours (pages 1573–1574): Miguel Bruguera
Chapter 19.8 Gallbladder Carcinoma (pages 1575–1582): Thomas A. Aloia, Christopher H. Crane and Jean?Nicolas Vauthey
Chapter 19.9 Cholangiocarcinoma (pages 1583–1605): Steven M. Strasberg and William G. Hawkins
Chapter 20.1 The Liver in Cardiovascular Disease (pages 1607–1615): Susan Tiukinhoy?Laing, Andres T. Blei and Mihai Gheorghiade
Chapter 20.2 The Liver in Lung Diseases (pages 1616–1621): Andres T. Blei and Jacob I. Sznajder
Chapter 20.3 The Effect of Gastrointestinal Diseases on the Liver and Biliary Tract (pages 1622–1633): Roger W. Chapman and Peter W. Angus
Chapter 20.4 Total Parenteral Nutrition?Related Liver Disease (pages 1634–1641): Sean W.P. Koppe and Alan L. Buchman
Chapter 20.5 The Effect of Skin Diseases on the Liver (pages 1642–1652): Daniel Glass and Malcolm Rustin
Chapter 20.6 The Liver in Urogenital Diseases (pages 1653–1661): Monica Guevara, Vicente Arroyo and Juan Rodes
Chapter 20.7 The Effect of Haematological and Lymphatic Diseases on the Liver (pages 1662–1670): Miguel Bruguera and Rosa Miquel
Chapter 20.8 The Liver in Graft?vs.?Host Disease (pages 1671–1679): Enric Carreras, Carmen Martinez and Miguel Bruguera
Chapter 20.9 The Effect of Endocrine Diseases on Liver Function (pages 1680–1693): Anthony J. DeSantis and Andres T. Blei
Chapter 20.10 Musculoskeletal Diseases and the Liver (pages 1694–1701): N. Guanabens, J. Van Den Bogaerde and H.L.C. Beynon
Chapter 20.11 Amyloidosis (pages 1702–1708): Philip N. Hawkins
Chapter 20.12 Hepatic Granulomas (pages 1709–1717): Laura M. Kulik and Andres T. Blei
Chapter 21.1 The Effect of Liver Disease on the Cardiovascular System (pages 1719–1731): Jens H. Henriksen and Soren Moller
Chapter 21.2 The Effect of Liver Disease on the Endocrine System (pages 1732–1766): Yolanta T. Kruszynska and Pierre M. Bouloux
Chapter 21.3 Haematological Abnormalities in Liver Disease (pages 1767–1779): Marco Senzolo and Andrew K. Burroughs
Chapter 21.4 Haemostasis in Liver Disease (pages 1780–1797): Stephen H. Caldwell, Patrick G. Northup and Vinay Sundaram
Chapter 21.5 The Effect of Liver Disease on the Gastrointestinal Tract (pages 1798–1803): Roger W. Chapman and Peter W. Angus
Chapter 21.6 The Effect of Liver Disease on the Skin (pages 1804–1814): Malcolm Rustin and Daniel Glass
Chapter 21.7 The Effect of Liver Disease on the Urogenital Tract (pages 1815–1821): Monica Guevara, Vicente Arroyo and Juan Rodes
Chapter 21.8 The Nervous System in Liver Disease (pages 1822–1828): Andres T. Blei
Chapter 21.9 The Effect of Liver Disease on Bone (pages 1829–1835): Juliet Compston
Chapter 21.10 The Effect of Liver Disease on Nutritional Status and Energy Metabolism (pages 1836–1842): Michael R. Charlton
Chapter 22.1 Paediatric Liver Diseases (pages 1843–1869): Marianne Samyn and Giorgina Mieli?Vergani
Chapter 22.2 Liver Diseases in the Elderly (pages 1870–1878): Oliver F.W. James
Chapter 22.3 Liver Diseases and Pregnancy (pages 1879–1895): Andrew K. Burroughs and Evangelos Cholongitas
Chapter 23.1 The General Management of Liver Diseases (pages 1897–1904): Dominique Guyader
Chapter 23.2 Nutritional Aspects of Liver and Biliary Disease (pages 1905–1911): Bernard Campillo
Chapter 23.3 Prescribing Drugs in Liver Disease (pages 1912–1921): Dominique Larrey and Georges?Philippe Pageaux
Chapter 23.4 Management of Pretransplant Patients (pages 1922–1930): Francois Durand
Chapter 24.1 General Surgical Aspects and the Risks of Liver Surgery in Patients with Hepatic Disease (pages 1931–1937): Jacques Belghiti and Satoshi Ogata
Chapter 24.2 Anaesthesia and Liver Disease (pages 1938–1944): Kalpana Reddy and Susan V. Mallett
Chapter 24.3 Postoperative Jaundice (pages 1945–1952): Peter Fickert and Michael Trauner
Chapter 24.4 Hepatobiliary Trauma (pages 1953–1961): K. Raj Prasad, Patrick A. Coughlin and Giles J. Toogood
Chapter 25.1 Surgical Techniques (pages 1963–1983): Peter Neuhaus, Ramon Charco, Josp Fuster Obregon, Constantino Fondevila, Juan Carlos Garcia?Valdecasas, Igal Kam, James Trotter and Gregory T. Everson
Chapter 25.2 Liver Transplantation: Indications, Contraindications and Results (pages 1984–1995): Gregory T. Everson and Fernando E. Membreno
Chapter 25.3 The Perioperative Care and Complications of Liver Transplantation (pages 1996–2002): Mark T. Keegan and David J. Plevak
Chapter 25.4 Immunosuppression (pages 2003–2009): James Neuberger
Chapter 25.5 Recurrent Disease and Management in Liver Transplantation (pages 2010–2018): Xavier Forns and Antoni Rimola
Chapter 25.6 Post?Transplantation Management and Complications (pages 2019–2026): Faouzi Saliba and Didier Samuel
Chapter 25.7 Liver Transplantation and Quality of Life (pages 2027–2031): Miguel Navasa and Juan Rodes
Chapter 25.8 Emerging Therapies (pages 2032–2052): Govardhana Rao Yannam, Jayanta Roy?Chowdhury, Ira J. Fox, Vanessa Stadlbauer and Rajiv Jalan
Chapter 26.1 Models in Clinical Hepatology (pages 2053–2064): W. Ray Kim
Chapter 26.2 Outcomes Research in Hepatology (pages 2065–2072): Raymond S. Koff
Chapter 26.3 Meta?Analysis (pages 2073–2079): Gioacchino Leandro and Andrew K. Burroughs
Chapter 26.4 Economic Considerations in Hepatology (pages 2080–2087): John B. Wong
Chapter 26.5 Development of the Liver Interactome: Mapping the Regulatory Networks (pages 2088–2095): Mario Pagano, Susana Neves, Ravi Iyengar and John Cijiang He