Guanine quartets : structure and application

Contents......Page 8
Introduction: From G-Quartet to G-Quadruplex and its Nanoarchitectures......Page 12
Guanylic acid Self-Assembly: 100 years on......Page 14
Functional Assemblies made from Supramolecular G-Quadruplexes......Page 26
Self-Assembly of Lipophilic Guanosines: Switching between different Assemblies......Page 39
Nanopatterning the Surface with ordered Supramolecular Architectures: Controlling the Self-Assembly of Guanine-based Hydrogen-Bonded Motifs......Page 51
Morphological Heterogeneity of Supramolecular G-DNA Polymers derived from Guanine Rich Oligonucleotides......Page 59
Thermondynamics of G-Quadrup1exes......Page 74
G-Quadruplex Nanostructures Probed at the Single Molecular Level by Force-Based Methods......Page 84
Introduction: Synthesis and Characterization......Page 98
Synthesis and Properties of Oligonucleotides Forming G-Quadruplexes......Page 100
Electrochemical Characterization of Guanine Quadruplexes......Page 111
AFM of Guanine Rich Oligonucleotide Surface Structures......Page 121
Solution Dynamics and Structure ofG-Quadruplexes Studied by Dynamic Light Scattering......Page 132
GMP-Quadruplex Structures in Dilute Solutions and in Condensed Phases: An X-Ray Scattering Analysis......Page 146
Temperature-Gradient Gel Electrophoresis: Unfolding of G-Quadruplexes......Page 158
Specific Behaviour of Guanosine in Liponucleoside Thin Films......Page 165
Theoretical Modelling, Analysis and Prediction......Page 176
Fundamentals and Applications of the Geometric Formalism of Quadruplex Folding......Page 178
Guanine, Xanthine and Uric Acid Assemblies: Comparative Theoretical and Experimental Studies......Page 190
Computational Methods for Studying G-Quadruplex Nuceic Acids......Page 205
Introduction: Recognition of Quadruplexes......Page 224
Biological Functions of G-Quadruplexes......Page 226
Regulation of Gene Transcription by DNA G-Quadruplexes......Page 234
The Reality of Quadruplex Nucleic Acids as a Therapeutic Target......Page 248
Screening for Quadmplex Binding Ligands: A Game of Chance?......Page 259
Recognition of G-Quadruplexes by Metal Complexes......Page 274
Introduction: Applications in Bioanalytics, Therapy and Molecular Electronics......Page 286
Catalytic G-Quadmplexes......Page 288
Catalytic G-Quadmplexes for the Detection of Telomerase Activity......Page 296
G-Quadruplex forming Oligonucleotides with Tailor-made Modifications as effective aptamers for Potential Therapeutic Applications......Page 303
Dep-Based Integration of G-Quadruplex Structures......Page 317
Conductive Behaviour of G4-DNA-Silver Nanoparticle Structures......Page 325
Novel Materials for Molecular Electronics- Synthese and Characterization of LongG4-DNA......Page 335
Subject Index......Page 348